Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Mady Elbahri (Lead / Corresponding author), Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort, Moheb Abdelaziz

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)
65 Downloads (Pure)


The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.

Original languageEnglish
Article number15319
Number of pages10
JournalNature Communications
Publication statusPublished - 12 May 2017


  • Nanoparticles
  • Nanotechnology in cancer
  • Phase transitions and critical phenomena
  • Synthesis and processing

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy


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