Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection

Suzanne M. Hingley-Wilson; Rosalyn Casey; David Connell; Samuel Bremang; Jason T Evans; Peter M. Hawkey; Grace E Smith; Annette Jepson; Stuart Philip; Onn Min Kon; Ajit Lalvani

doi:10.3201/1907.130313

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection

Suzanne M. Hingley-Wilson (Lead / Corresponding author)
, Rosalyn Casey
, David Connell
, Samuel Bremang
, Jason T Evans
, Peter M. Hawkey
, Grace E Smith
, Annette Jepson
, Stuart Philip
, Onn Min Kon
, Ajit Lalvani

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

Original language	English
Pages (from-to)	1138-1141
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	19
Issue number	7
DOIs	https://doi.org/10.3201/1907.130313
Publication status	Published - Jul 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Antitubercular Agents/pharmacology
Coinfection/diagnosis
Culture Techniques
Delayed Diagnosis
Drug Resistance, Multiple, Bacterial
Drug Therapy, Combination
Ethambutol/pharmacology
Humans
Isoniazid/pharmacology
Male
Minisatellite Repeats
Molecular Diagnostic Techniques
Multilocus Sequence Typing
Mycobacterium tuberculosis/genetics
Treatment Outcome
Tuberculosis, Multidrug-Resistant/diagnosis
Tuberculosis, Pulmonary/diagnosis

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10.3201/1907.130313

Cite this

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title = "Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection",

abstract = "Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.",

keywords = "Aged, Antitubercular Agents/pharmacology, Coinfection/diagnosis, Culture Techniques, Delayed Diagnosis, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Ethambutol/pharmacology, Humans, Isoniazid/pharmacology, Male, Minisatellite Repeats, Molecular Diagnostic Techniques, Multilocus Sequence Typing, Mycobacterium tuberculosis/genetics, Treatment Outcome, Tuberculosis, Multidrug-Resistant/diagnosis, Tuberculosis, Pulmonary/diagnosis",

author = "Hingley-Wilson, \{Suzanne M.\} and Rosalyn Casey and David Connell and Samuel Bremang and Evans, \{Jason T\} and Hawkey, \{Peter M.\} and Smith, \{Grace E\} and Annette Jepson and Stuart Philip and Kon, \{Onn Min\} and Ajit Lalvani",

year = "2013",

month = jul,

doi = "10.3201/1907.130313",

language = "English",

volume = "19",

pages = "1138--1141",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "7",

}

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T1 - Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection

AU - Hingley-Wilson, Suzanne M.

AU - Casey, Rosalyn

AU - Connell, David

AU - Bremang, Samuel

AU - Evans, Jason T

AU - Hawkey, Peter M.

AU - Smith, Grace E

AU - Jepson, Annette

AU - Philip, Stuart

AU - Kon, Onn Min

AU - Lalvani, Ajit

PY - 2013/7

Y1 - 2013/7

N2 - Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

AB - Infections with >1 Mycobacterium tuberculosis strain(s) are underrecognized. We show, in vitro and in vivo, how first-line treatment conferred a competitive growth advantage to amplify a multidrug-resistant M. tuberculosis strain in a patient with mixed infection. Diagnostic techniques that identify mixed tubercle bacilli populations are needed to curb the spread of multidrug resistance.

KW - Aged

KW - Antitubercular Agents/pharmacology

KW - Coinfection/diagnosis

KW - Culture Techniques

KW - Delayed Diagnosis

KW - Drug Resistance, Multiple, Bacterial

KW - Drug Therapy, Combination

KW - Ethambutol/pharmacology

KW - Humans

KW - Isoniazid/pharmacology

KW - Male

KW - Minisatellite Repeats

KW - Molecular Diagnostic Techniques

KW - Multilocus Sequence Typing

KW - Mycobacterium tuberculosis/genetics

KW - Treatment Outcome

KW - Tuberculosis, Multidrug-Resistant/diagnosis

KW - Tuberculosis, Pulmonary/diagnosis

U2 - 10.3201/1907.130313

DO - 10.3201/1907.130313

M3 - Article

C2 - 23764343

SN - 1080-6040

VL - 19

SP - 1138

EP - 1141

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 7

ER -

Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection

Abstract

UN SDGs

Keywords

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