@article{c3d58e5a54554732b1ff21dd8d8a061f,
title = "Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis",
abstract = "Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD).",
keywords = "Filaggrin, Eczema, Ichthyosis, Keratinization, Skin barrier, Atopy, Skin, Genodermatosis, Genetics, Mutation",
author = "Toshifumi Nomura and Aileen Sandilands and Masashi Akiyama and Haihui Liao and Evans, {Alan T.} and Kaori Sakai and Mitsuhito Ota and Hisashi Sugiura and Kazuo Yamamoto and Hiroshi Sato and Palmer, {Colin N. A.} and Smith, {Frances J. D.} and McLean, {W. H. Irwin} and Hiroshi Shimizu",
note = "dc.publisher: Elsevier Major contributing author involved in the overall strategy, planning, experimental work, analysis and writing of the first paper to describe mutations in the filaggrin gene in the Far Eastern population, that the mutations predispose to atopic dermatitis and the first definitive gene association for eczema in the Japanese population. ",
year = "2007",
doi = "10.1016/j.jaci.2006.12.646",
language = "English",
volume = "119",
pages = "434--440",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Elsevier",
number = "2",
}