Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis

Toshifumi Nomura, Aileen Sandilands, Masashi Akiyama, Haihui Liao, Alan T. Evans, Kaori Sakai, Mitsuhito Ota, Hisashi Sugiura, Kazuo Yamamoto, Hiroshi Sato, Colin N. A. Palmer, Frances J. D. Smith, W. H. Irwin McLean, Hiroshi Shimizu

    Research output: Contribution to journalArticlepeer-review

    174 Citations (Scopus)

    Abstract

    Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD).
    Original languageEnglish
    Pages (from-to)434-440
    Number of pages7
    JournalJournal of Allergy and Clinical Immunology
    Volume119
    Issue number2
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Filaggrin
    • Eczema
    • Ichthyosis
    • Keratinization
    • Skin barrier
    • Atopy
    • Skin
    • Genodermatosis
    • Genetics
    • Mutation

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