Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

Swarup Kumar Maji; Sivaramapanicker Sreejith; James Joseph; Manjing Lin; Tingchao He; Yan Tong; Handong Sun; Sidney Wing Kwong Yu; Yanli Zhao

doi:10.1002/adma.201400831

Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

Swarup Kumar Maji, Sivaramapanicker Sreejith, James Joseph, Manjing Lin, Tingchao He, Yan Tong, Handong Sun, Sidney Wing Kwong Yu (Lead / Corresponding author), Yanli Zhao (Lead / Corresponding author)

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

156 Citations (Scopus)

Abstract

An inclusion complex of NaYF₄:Yb³⁺,Er³⁺ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF₄:Yb ³⁺,Er³⁺ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

Original language	English
Pages (from-to)	5633-5638
Number of pages	6
Journal	Advanced Materials
Volume	26
Issue number	32
Early online date	10 Jun 2014
DOIs	https://doi.org/10.1002/adma.201400831
Publication status	Published - 27 Aug 2014

Keywords

contrast agent
live mice
photoacoustic imaging
upconversion nanoparticles

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201400831

Cite this

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abstract = "An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.",

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AU - Maji, Swarup Kumar

AU - Sreejith, Sivaramapanicker

AU - Joseph, James

AU - Lin, Manjing

AU - He, Tingchao

AU - Tong, Yan

AU - Sun, Handong

AU - Yu, Sidney Wing Kwong

AU - Zhao, Yanli

PY - 2014/8/27

Y1 - 2014/8/27

N2 - An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

AB - An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

KW - contrast agent

KW - live mice

KW - photoacoustic imaging

KW - upconversion nanoparticles

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ER -

Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

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Joseph, James

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Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

Abstract

Keywords

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Joseph, James

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