Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

Swarup Kumar Maji, Sivaramapanicker Sreejith, James Joseph, Manjing Lin, Tingchao He, Yan Tong, Handong Sun, Sidney Wing Kwong Yu (Lead / Corresponding author), Yanli Zhao (Lead / Corresponding author)

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

Original languageEnglish
Pages (from-to)5633-5638
Number of pages6
JournalAdvanced Materials
Volume26
Issue number32
Early online date10 Jun 2014
DOIs
Publication statusPublished - 27 Aug 2014

Keywords

  • contrast agent
  • live mice
  • photoacoustic imaging
  • upconversion nanoparticles

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