Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

TY - JOUR

T1 - Upconversion nanoparticles as a contrast agent for photoacoustic imaging in live mice

AU - Maji, Swarup Kumar

AU - Sreejith, Sivaramapanicker

AU - Joseph, James

AU - Lin, Manjing

AU - He, Tingchao

AU - Tong, Yan

AU - Sun, Handong

AU - Yu, Sidney Wing Kwong

AU - Zhao, Yanli

PY - 2014/8/27

Y1 - 2014/8/27

N2 - An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

AB - An inclusion complex of NaYF4:Yb3+,Er3+ upconversion nanoparticles with α-cyclodextrin in aqueous conditions exhibits luminescence quenching when excited at 980 nm. This non-radiative relaxation leads to an unprecedented photoacoustic signal enhancement. In vivo localization of α-cyclodextrin-covered NaYF4:Yb 3+,Er3+ is demonstrated using photoacoustic tomography in live mice, showing its high capability for photoacoustic imaging.

KW - contrast agent

KW - live mice

KW - photoacoustic imaging

KW - upconversion nanoparticles

UR - https://www.scopus.com/pages/publications/84906783536

U2 - 10.1002/adma.201400831

DO - 10.1002/adma.201400831

M3 - Article

C2 - 24913756

AN - SCOPUS:84906783536

SN - 0935-9648

VL - 26

SP - 5633

EP - 5638

JO - Advanced Materials

JF - Advanced Materials

IS - 32

ER -