Uptake of hepatitis C specialist services and treatment following diagnosis by dried blood spot in Scotland

Georgina McAllister (Lead / Corresponding author), Hamish Innes, Allan Mcleod, John F. Dillon, Peter C. Hayes, Ray Fox, Stephen T. Barclay, Kate Templeton, Celia Aitken, Rory Gunson, David Goldberg, Sharon J. Hutchinson

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    Background

    Dried blood spot (DBS) testing for hepatitis C (HCV) was introduced to Scotland in 2009. This minimally invasive specimen provides an alternative to venipuncture and can overcome barriers to testing in people who inject drugs (PWID).
    Objectives

    The objective of this study was to determine rates and predictors of: exposure to HCV, attendance at specialist clinics and anti-viral treatment initiation among the DBS tested population in Scotland.
    Study design

    DBS testing records were deterministically linked to the Scottish HCV Clinical database prior to logistic regression analysis.
    Results

    In the first two years of usage in Scotland, 1322 individuals were tested by DBS of which 476 were found to have an active HCV infection. Linkage analysis showed that 32% had attended a specialist clinic within 12 months of their specimen collection date and 18% had begun anti-viral therapy within 18 months of their specimen collection date. A significantly reduced likelihood of attendance at a specialist clinic was evident amongst younger individuals (<35 years), those of unknown ethnic origin and those not reporting injecting drug use as a risk factor.
    Conclusion

    We conclude that DBS testing in non-clinical settings has the potential to increase diagnosis and, with sufficient support, treatment of HCV infection among PWID.
    Original languageEnglish
    Pages (from-to)359-364
    Number of pages6
    JournalJournal of Clinical Virology
    Volume61
    Issue number3
    DOIs
    Publication statusPublished - Nov 2014

      Fingerprint

    Cite this

    McAllister, G., Innes, H., Mcleod, A., Dillon, J. F., Hayes, P. C., Fox, R., Barclay, S. T., Templeton, K., Aitken, C., Gunson, R., Goldberg, D., & Hutchinson, S. J. (2014). Uptake of hepatitis C specialist services and treatment following diagnosis by dried blood spot in Scotland. Journal of Clinical Virology , 61(3), 359-364. https://doi.org/10.1016/j.jcv.2014.09.004