Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis

J. Stochl (Lead / Corresponding author), T. Croudace, J. Perez, M. Birchwood, H. Lester, M. Marshall, T. Amos, V. Sharma, D. Fowler, P. B. Jones, The National Eden Study Team

    Research output: Contribution to journalArticle

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    Abstract

    PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.
    Original languageEnglish
    Pages (from-to)1055-1063
    Number of pages9
    JournalQuality of Life Research
    Volume22
    Issue number5
    DOIs
    Publication statusPublished - Jun 2013

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    Psychotic Disorders
    Young Adult
    Quality of Life
    Psychometrics
    Anxiety
    Depression
    Cost-Benefit Analysis
    Psychiatry
    Surveys and Questionnaires

    Keywords

    • Public Health, Environmental and Occupational Health

    Cite this

    Stochl, J. ; Croudace, T. ; Perez, J. ; Birchwood, M. ; Lester, H. ; Marshall, M. ; Amos, T. ; Sharma, V. ; Fowler, D. ; Jones, P. B. ; The National Eden Study Team . / Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis. In: Quality of Life Research. 2013 ; Vol. 22, No. 5. pp. 1055-1063.
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    abstract = "PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.",
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    Stochl, J, Croudace, T, Perez, J, Birchwood, M, Lester, H, Marshall, M, Amos, T, Sharma, V, Fowler, D, Jones, PB & The National Eden Study Team 2013, 'Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis', Quality of Life Research, vol. 22, no. 5, pp. 1055-1063. https://doi.org/10.1007/s11136-012-0222-7

    Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis. / Stochl, J. (Lead / Corresponding author); Croudace, T.; Perez, J.; Birchwood, M.; Lester, H.; Marshall, M.; Amos, T.; Sharma, V.; Fowler, D.; Jones, P. B.; The National Eden Study Team .

    In: Quality of Life Research, Vol. 22, No. 5, 06.2013, p. 1055-1063.

    Research output: Contribution to journalArticle

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    T1 - Usefulness of EQ-5D for evaluation of health-related quality of life in young adults with first-episode psychosis

    AU - Stochl, J.

    AU - Croudace, T.

    AU - Perez, J.

    AU - Birchwood, M.

    AU - Lester, H.

    AU - Marshall, M.

    AU - Amos, T.

    AU - Sharma, V.

    AU - Fowler, D.

    AU - Jones, P. B.

    AU - The National Eden Study Team

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    N2 - PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.

    AB - PURPOSE: To evaluate the psychometric properties of the EQ-5D and the usefulness of this instrument in psychiatric practice as a measure of health-related quality of life (HRQoL) in a sample of young adults with first-episode psychosis. METHODS: The validity of individual questionnaire items is studied using an Item Response/Latent Trait Theory modeling approach. Sensitivity of response patterns on EQ-5D items to particular diagnostic subtypes of psychosis is investigated using a finite mixture modeling approach through latent class analysis. Finally, a structural equation modeling framework is used to study differential item functioning via a multigroup approach. RESULTS: Results suggest that the data closely correspond to the Rasch Rating Scale Model, and therefore that EQ-5D latent scores are equal interval measures. Despite comprising relatively few items, the instrument yields reliable measures of HRQoL for group comparisons and cost-effectiveness evaluation, but EQ-5D score is too imprecise for the assessment of HRQoL for clinical purposes at the individual level. A significant relationship was found between EQ-5D responses and type of psychosis due to inclusion of item anxiety/depression in EQ-5D. Two items (anxiety/depression, functioning in usual activities) showed an ethnicity bias. CONCLUSIONS: Psychometric evidence confirmed the EQ-5D to be a valid, interval measure that is scalable according to Rasch principles.

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