Using a steroid-sparing tool in paediatric inflammatory bowel disease to evaluate steroid use and dependency

Rachel E. Harris, Wei Sim, Harry Sutton, Vikki Garrick, Lee Curtis, Lisa Gervais, Victoria Merrick, Andrew R. Barclay, Diana M. Flynn, Rachel Tayler, Richard Hansen, Richard K. Russell

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Objectives: The aim of the study was to evaluate the use of steroids within the paediatric inflammatory bowel disease (PIBD) population at a tertiary paediatric centre over a year; to identify cases of steroid dependency; and assess factors associated with steroid excess. 

    Methods: The prevalent PIBD population (May 1, 2017-April 30, 2018) were reviewed. Data were collected retrospectively from patient records and entered into an online steroid assessment tool (modified for paediatrics). 

    Results: A total of 229 patients (181 Crohn disease, 31 ulcerative colitis [UC], and 17 inflammatory bowel disease-unclassified) were included. Of the 229 patients 38 (16.6%) received oral steroids; 12 of 38 (31.6%) receiving >3-month course. Eleven of 38 (28.9%) received >1 steroid course (maximum 2). Of the 229 patients 37 (16.2%) had exclusive enteral nutrition, with 26 of 37 (11.4% total cohort) avoiding steroid use during the study period. Quiescent disease activity had a negative correlation with steroid use (11/127 [8.7%] vs 27/102 [26.5%] P < 0.01), and steroid dependency (3/127 [2.4%] vs 12/102 [11.8%] P < 0.01). Patients with UC were more likely to be steroid dependent (5/31 [16.1%] UC vs 10/198 [5.1%]; P = 0.02); as were network-managed patients (8/11 [72.7%] vs 7/27 [25.9%]; P = 0.01). Fourteen of 15 (93.3%) of steroid-dependent patients had active steroid sparing strategies in place (eg, commencement, switching, or optimization of therapies). 

    Conclusions: We have described rates of steroid use and dependency within our PIBD population. Exclusive enteral nutrition served as a steroid sparing tool in 11.4% of the total cohort. Replication of this study in other paediatric centres would allow comparative analysis.

    Original languageEnglish
    Pages (from-to)557-563
    Number of pages7
    JournalJournal of Pediatric Gastroenterology and Nutrition
    Volume69
    Issue number5
    DOIs
    Publication statusPublished - Nov 2019

    Keywords

    • corticosteroids
    • Crohn disease
    • Inflammatory bowel disease
    • paediatric gastroenterology
    • ulcerative colitis

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Gastroenterology

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