Using animal models to understand cancer pain in humans

Gillian L. Currie; Emily S. Sena; Marie T. Fallon; Malcolm R. Macleod; Lesley A. Colvin

doi:10.1007/s11916-014-0423-6

Using animal models to understand cancer pain in humans

Gillian L. Currie, Emily S. Sena, Marie T. Fallon, Malcolm R. Macleod (Lead / Corresponding author), Lesley A. Colvin

Population Health and Genomics

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.

Original language	English
Article number	423
Number of pages	8
Journal	Current Pain and Headache Reports
Volume	18
Issue number	6
Early online date	24 Apr 2014
DOIs	https://doi.org/10.1007/s11916-014-0423-6
Publication status	Published - Jun 2014

Keywords

Cancer pain
Animal modes
Neuropathic pain
Inflammation
Opioid treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11916-014-0423-6

Cite this

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title = "Using animal models to understand cancer pain in humans",

abstract = "Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.",

keywords = "Cancer pain, Animal modes, Neuropathic pain, Inflammation, Opioid treatment",

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AU - Currie, Gillian L.

AU - Sena, Emily S.

AU - Fallon, Marie T.

AU - Macleod, Malcolm R.

AU - Colvin, Lesley A.

PY - 2014/6

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N2 - Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.

AB - Cancer pain is not a single entity but a complex pain state involving different pain syndromes, with inflammatory, neuropathic, compressive, and ischaemic mechanisms. Current therapeutic regimens are based largely on opioids, although opioid treatment can lead to many side effects. Studies using animal models of cancer pain are aimed at understanding cancer pain and developing novel therapies. The most frequently reported models are of bone cancer pain, predominantly modelling pain associated with tumour growth within bone marrow. Here we summarise recent findings from studies using animal models of cancer pain and discuss the methodological quality of these studies.

KW - Cancer pain

KW - Animal modes

KW - Neuropathic pain

KW - Inflammation

KW - Opioid treatment

U2 - 10.1007/s11916-014-0423-6

DO - 10.1007/s11916-014-0423-6

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VL - 18

JO - Current Pain and Headache Reports

JF - Current Pain and Headache Reports

IS - 6

M1 - 423

ER -

Using animal models to understand cancer pain in humans

Abstract

Keywords

UN SDGs

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