Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Tim W. P. Devling, Christopher D. Lindsay, Lesley I. McLellan, Michael McMahon, John D. Hayes

    Research output: Contribution to journalArticle

    100 Citations (Scopus)

    Abstract

    A duplex 21 nucleotide small interfering RNA (siRNA) against human Keap1 is described that represents a unique class of cancer chemopreventive agent. This siRNA can knockdown Keap1 mRNA and thereby relieve negative regulation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-mediated gene expression. The siRNA lowered endogenous Keap1 mRNA to
    Original languageEnglish
    Pages (from-to)7280-7285A
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume102
    Issue number20
    DOIs
    Publication statusPublished - 2005

    Keywords

    • Antioxidants
    • Chemoprevention
    • Glutathione
    • Nuclear factor erythroid 2 p45-related factor 2
    • Aldo-keto reductase

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