Projects per year
Abstract
Background: Objective assessment of symptoms in bronchiectasis is important for research and in clinical practice. The COPD Assessment Test (CAT) is a short, simple assessment tool widely used in COPD. The items included in the CAT are not specific to COPD and also reflect the dominant symptoms of bronchiectasis. We therefore performed a study to validate the CAT as an outcome measure in bronchiectasis.
Methods: The CAT was administered to two cohorts of bronchiectasis patients along with other quality of life questionnaires. Patients underwent comprehensive clinical assessment. One cohort had repeated questionnaires collected before-and-after treatment of acute exacerbations. We analyzed convergent validity, repeatability, and responsiveness of the score and calculated the minimum clinically important difference (MCID) using a combination of distribution and anchor-based methods.
Results: In both cohorts there were positive correlations between the CAT and the St. George's Respiratory Questionnaire (r = 0.90, P < .0001 and r = 0.87, P < .0001). There was an inverse relationship between CAT and Quality of Life - Bronchiectasis Respiratory Symptoms Scale (r = -0.75, P < .0001) and Leicester Cough Questionnaire score (r = -0.77, P < .0001). Patients with more severe disease, based on the bronchiectasis severity index, had significantly higher CAT scores. CAT also correlated with FEV 1 % predicted and 6-min walk distance (6MWD). CAT increased significantly at exacerbation and fell at recovery. The intraclass correlation coefficient for two measurements four-weeks apart while clinically stable was 0.88 (95% CI, 0.73-0.95, P < .0001). An MCID of 4 was most consistent.
Conclusions: CAT is a valid, responsive symptom assessment tool in bronchiectasis. The MCID is estimated as 4 points.
Original language | English |
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Pages (from-to) | 815-823 |
Number of pages | 9 |
Journal | Chest |
Volume | 157 |
Issue number | 4 |
Early online date | 12 Nov 2019 |
DOIs | |
Publication status | Published - Apr 2020 |
Keywords
- bronchiectasis
- outcomes
- questionnaire
- severity
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Dive into the research topics of 'Validation of the COPD Assessment Test (CAT) as an outcome measure in bronchiectasis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Pregnancy Zone Protein in the Lung - Investigating Gender Differences in Development and Prognosis of Bronchiectasis (Clinical Academic Fellowship)
Chalmers, J. (Investigator) & Finch, S. (Investigator)
1/02/17 → 31/01/20
Project: Research
Student theses
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Sex related differences in clinical characteristics, quality of life and inflammation in bronchiectasis
Finch, S. M. (Author), Chalmers, J. (Supervisor) & Shoemark, A. (Supervisor), 2021Student thesis: Doctoral Thesis › Doctor of Philosophy
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