Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Pharmacogenomics in Childhood Asthma Consortium; Steve Turner; Ben Francis; Nuha Wani; Susanne Vijverberg; Maria Pino-Yanes; Somnath Mukhopadhyay; Roger Tavendale; Colin Palmer; Esteban G Burchard; Simon Kebede Merid; Erik Melén; Anke H Maitland-van der Zee

doi:10.2217/pgs-2018-0027

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Pharmacogenomics in Childhood Asthma Consortium, Steve Turner (Lead / Corresponding author), Ben Francis, Nuha Wani, Susanne Vijverberg, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Colin Palmer, Esteban G Burchard, Simon Kebede Merid, Erik Melén, Anke H Maitland-van der Zee

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

Original language	English
Pages (from-to)	707-713
Number of pages	7
Journal	Pharmacogenomics
Volume	19
Issue number	8
Early online date	22 May 2018
DOIs	https://doi.org/10.2217/pgs-2018-0027
Publication status	Published - Jun 2018

Keywords

asthma
child
exacerbation
glutathione S-transferase
severity
tobacco smoke

ASJC Scopus subject areas

Molecular Medicine
Genetics
Pharmacology

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10.2217/pgs-2018-0027

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Pharmacogenomics in Childhood Asthma Consortium, Turner, S., Francis, B., Wani, N., Vijverberg, S., Pino-Yanes, M., Mukhopadhyay, S., Tavendale, R., Palmer, C., Burchard, E. G., Merid, S. K., Melén, E., & Maitland-van der Zee, A. H. (2018). Variants in genes coding for glutathione S-transferases and asthma outcomes in children. Pharmacogenomics, 19(8), 707-713. https://doi.org/10.2217/pgs-2018-0027

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title = "Variants in genes coding for glutathione S-transferases and asthma outcomes in children",

abstract = "Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.",

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volume = "19",

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Pharmacogenomics in Childhood Asthma Consortium, Turner, S, Francis, B, Wani, N, Vijverberg, S, Pino-Yanes, M, Mukhopadhyay, S, Tavendale, R, Palmer, C, Burchard, EG, Merid, SK, Melén, E & Maitland-van der Zee, AH 2018, 'Variants in genes coding for glutathione S-transferases and asthma outcomes in children', Pharmacogenomics, vol. 19, no. 8, pp. 707-713. https://doi.org/10.2217/pgs-2018-0027

TY - JOUR

T1 - Variants in genes coding for glutathione S-transferases and asthma outcomes in children

AU - Pharmacogenomics in Childhood Asthma Consortium

AU - Turner, Steve

AU - Francis, Ben

AU - Wani, Nuha

AU - Vijverberg, Susanne

AU - Pino-Yanes, Maria

AU - Mukhopadhyay, Somnath

AU - Tavendale, Roger

AU - Palmer, Colin

AU - Burchard, Esteban G

AU - Merid, Simon Kebede

AU - Melén, Erik

AU - Maitland-van der Zee, Anke H

PY - 2018/6

Y1 - 2018/6

N2 - Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

AB - Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nucleotide polymorphism (GSTP1) was determined in all cohorts (3692 children) and GSTM1 and GSTT1 null genotype were determined in three cohorts (2362 children). GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity. Interactions between GST genotypes and SHS exposure or asthma severity with the study outcomes were nonsignificant. We find no convincing evidence that the GST genotypes studied are related to asthma outcomes.

KW - asthma

KW - child

KW - exacerbation

KW - glutathione S-transferase

KW - severity

KW - tobacco smoke

U2 - 10.2217/pgs-2018-0027

DO - 10.2217/pgs-2018-0027

M3 - Article

C2 - 29785881

SN - 1462-2416

VL - 19

SP - 707

EP - 713

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 8

ER -

Variants in genes coding for glutathione S-transferases and asthma outcomes in children

Abstract

Keywords

ASJC Scopus subject areas

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