Variants in the nestin gene and coronary heart disease

Weihua Meng, Chris C. Patterson, Christine Belton, Anne Hughes, Pascal P. McKeown

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)


    Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported.

    Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02).

    Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.

    Original languageEnglish
    Pages (from-to)1538-1539
    Number of pages2
    JournalCirculation Journal
    Issue number9
    Publication statusPublished - 2008


    • coronary heart disease
    • polymorphism
    • nestin
    • CELLS


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