Variants in the nestin gene and coronary heart disease

Weihua Meng; Chris C. Patterson; Christine Belton; Anne Hughes; Pascal P. McKeown

doi:10.1253/circj.CJ-08-0262

Variants in the nestin gene and coronary heart disease

Weihua Meng, Chris C. Patterson, Christine Belton, Anne Hughes, Pascal P. McKeown

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported.

Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02).

Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.

Original language	English
Pages (from-to)	1538-1539
Number of pages	2
Journal	Circulation Journal
Volume	72
Issue number	9
DOIs	https://doi.org/10.1253/circj.CJ-08-0262
Publication status	Published - 2008

Keywords

coronary heart disease
polymorphism
nestin
CELLS

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https://www.jstage.jst.go.jp/browse/circj

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title = "Variants in the nestin gene and coronary heart disease",

abstract = "Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.",

keywords = "coronary heart disease, polymorphism, nestin, CELLS",

author = "Weihua Meng and Patterson, {Chris C.} and Christine Belton and Anne Hughes and McKeown, {Pascal P.}",

year = "2008",

doi = "10.1253/circj.CJ-08-0262",

language = "English",

volume = "72",

pages = "1538--1539",

journal = "Circulation Journal",

issn = "1346-9843",

publisher = "Japanese Circulation Society",

number = "9",

}

TY - JOUR

T1 - Variants in the nestin gene and coronary heart disease

AU - Meng, Weihua

AU - Patterson, Chris C.

AU - Belton, Christine

AU - Hughes, Anne

AU - McKeown, Pascal P.

PY - 2008

Y1 - 2008

N2 - Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.

AB - Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported. Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02). Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.

KW - coronary heart disease

KW - polymorphism

KW - nestin

KW - CELLS

U2 - 10.1253/circj.CJ-08-0262

DO - 10.1253/circj.CJ-08-0262

M3 - Article

SN - 1346-9843

VL - 72

SP - 1538

EP - 1539

JO - Circulation Journal

JF - Circulation Journal

IS - 9

ER -

Variants in the nestin gene and coronary heart disease

Abstract

Keywords

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