Variants in the nestin gene and coronary heart disease

Weihua Meng, Chris C. Patterson, Christine Belton, Anne Hughes, Pascal P. McKeown

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    4 Citations (Scopus)

    Abstract

    Background. The intermediate filament protein, nestin, may play a role in tissue regeneration and nestin expression has been detected in coronary atherosclerotic plaques. To date, no population-based studies concerning the role of the nestin gene in coronary heart disease (CHD) have been reported.

    Methods and Results. The 3 SNPs in the nestin gene were genotyped in 1,494 individuals from 580 Irish families. rs11582300 and rs3748570 were associated with early-onset CHD (p=0.04 and p=0.02).

    Conclusion. Nestin gene variants are associated with early-onset CHID. Further research on nestin's role in atherosclerosis is required.

    Original languageEnglish
    Pages (from-to)1538-1539
    Number of pages2
    JournalCirculation Journal
    Volume72
    Issue number9
    DOIs
    Publication statusPublished - 2008

    Keywords

    • coronary heart disease
    • polymorphism
    • nestin
    • CELLS

    Cite this

    Meng, W., Patterson, C. C., Belton, C., Hughes, A., & McKeown, P. P. (2008). Variants in the nestin gene and coronary heart disease. Circulation Journal, 72(9), 1538-1539. https://doi.org/10.1253/circj.CJ-08-0262