Variants of the peroxisome proliferator-activated receptor γ- and β-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children

Joanne E. Cecil (Lead / Corresponding author), Colin N. A. Palmer, Bettina Fischer, Peter Watt, Deborah J. Wallis, Inez Murrie, Marion M. Hetherington

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    Background: Young children can regulate energy precisely in the short term, showing the potential for an innate compensation mechanism of eating behavior. However, data suggest that precise compensation is attenuated as a function of increasing adiposity, parental feeding style, and age. Common variation in candidate obesity genes may account for some of the individual variation observed in short-term energy compensation. Polymorphisms in the peroxisome proliferator-activated receptor γ (PPARG) and β-adrenergic receptor (ADRB3) genes have been linked to increased body mass index (BMI; in kg/m2), obesity, and more recently dietary nutrients and preferences. In addition, common variation in ADRB3 interacts with PPARG to modulate adult body weight.

    Objective: This study investigated whether variants in these genes were associated with measurable effects on child eating behavior.

    Design: Children (n = 84) aged 4-10 y were prospectively selected for variants of the PPARG locus (Pro12Ala, C1431T). Heights and weights were measured. Energy intake from a test meal was measured 90 min after ingestion of a no-energy (NE), low-energy (LE), or high-energy (HE) preload, and the compensation index (COMPX) was calculated.

    Results: BMI differed significantly by gene model, whereby Pro12Ala was associated with a lower BMI. Poor COMPX was associated with the PPARG T1431 allele (P = 0.009). There was a significant interaction between COMPX and the ADRB3 Trp64Arg variant in modulating compensation (P = 0.003), whereas the Arg64 allele was associated with good compensation (P = 0.001).

    Conclusions: This is the first study to suggest that a genetic interaction involving ADRB3 and PPARG variants influences eating behavior in children.

    Original languageEnglish
    Pages (from-to)167-173
    Number of pages7
    JournalAmerican Journal of Clinical Nutrition
    Volume86
    Issue number1
    Early online date1 Jul 2007
    DOIs
    Publication statusPublished - Jul 2007

    Keywords

    • BMI
    • Body mass index
    • Children
    • Eating behavior
    • Energy compensation
    • Pparg gene variants

    Fingerprint Dive into the research topics of 'Variants of the peroxisome proliferator-activated receptor γ- and β-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children'. Together they form a unique fingerprint.

  • Cite this