Vascular damage and factor-VIII-related antigen in the rheumatic diseases

J. J. F. Belch, A. A. Zoma, I. M. Richards, K. McLaughlin, C. D. Forbes, R. D. Sturrock

    Research output: Contribution to journalArticle

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    Abstract

    Factor-VIII-Related antigen (VIII R:Ag) is known to be produced by the blood vessel wall. Noxious stimuli increase endothelial release of VIII R:Ag. It might be expected that the development of vasculitis would be associated with increased levels of VIII R:Ag. To investigate this, eight different groups of subjects were studied: 25 patients with systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis (RA) plus vasculitis, 19 with systemic vasculitis and 14 with atherosclerosis. These groups were compared to 29 patients with primary Raynaud's disease, 15 with RA without vasculitis and 50 controls. Results showed that where there was evidence of vascular disease, then VIII R:Ag was elevated. VIII R:Ag appeared to be a more specific marker for vascular damage than erythrocyte sedimentation rate or C-reactive protein. Longitudinal studies in 11 patients showed good correlation between progression of vascular disease and VIII R:Ag.
    Original languageEnglish
    Pages (from-to)107-111
    Number of pages5
    JournalRheumatology international
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - 1987

    Fingerprint

    von Willebrand Factor
    Vasculitis
    Rheumatic Diseases
    Vascular Diseases
    Blood Vessels
    Rheumatoid Arthritis
    Antigens
    Systemic Vasculitis
    Raynaud Disease
    Systemic Scleroderma
    Blood Sedimentation
    Systemic Lupus Erythematosus
    C-Reactive Protein
    Longitudinal Studies
    Atherosclerosis
    vascular factor

    Cite this

    Belch, J. J. F., Zoma, A. A., Richards, I. M., McLaughlin, K., Forbes, C. D., & Sturrock, R. D. (1987). Vascular damage and factor-VIII-related antigen in the rheumatic diseases. Rheumatology international, 7(3), 107-111. https://doi.org/10.1007/BF00270462
    Belch, J. J. F. ; Zoma, A. A. ; Richards, I. M. ; McLaughlin, K. ; Forbes, C. D. ; Sturrock, R. D. / Vascular damage and factor-VIII-related antigen in the rheumatic diseases. In: Rheumatology international. 1987 ; Vol. 7, No. 3. pp. 107-111.
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    abstract = "Factor-VIII-Related antigen (VIII R:Ag) is known to be produced by the blood vessel wall. Noxious stimuli increase endothelial release of VIII R:Ag. It might be expected that the development of vasculitis would be associated with increased levels of VIII R:Ag. To investigate this, eight different groups of subjects were studied: 25 patients with systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis (RA) plus vasculitis, 19 with systemic vasculitis and 14 with atherosclerosis. These groups were compared to 29 patients with primary Raynaud's disease, 15 with RA without vasculitis and 50 controls. Results showed that where there was evidence of vascular disease, then VIII R:Ag was elevated. VIII R:Ag appeared to be a more specific marker for vascular damage than erythrocyte sedimentation rate or C-reactive protein. Longitudinal studies in 11 patients showed good correlation between progression of vascular disease and VIII R:Ag.",
    author = "Belch, {J. J. F.} and Zoma, {A. A.} and Richards, {I. M.} and K. McLaughlin and Forbes, {C. D.} and Sturrock, {R. D.}",
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    Belch, JJF, Zoma, AA, Richards, IM, McLaughlin, K, Forbes, CD & Sturrock, RD 1987, 'Vascular damage and factor-VIII-related antigen in the rheumatic diseases', Rheumatology international, vol. 7, no. 3, pp. 107-111. https://doi.org/10.1007/BF00270462

    Vascular damage and factor-VIII-related antigen in the rheumatic diseases. / Belch, J. J. F.; Zoma, A. A.; Richards, I. M.; McLaughlin, K.; Forbes, C. D.; Sturrock, R. D.

    In: Rheumatology international, Vol. 7, No. 3, 1987, p. 107-111.

    Research output: Contribution to journalArticle

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    AU - Belch, J. J. F.

    AU - Zoma, A. A.

    AU - Richards, I. M.

    AU - McLaughlin, K.

    AU - Forbes, C. D.

    AU - Sturrock, R. D.

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    N2 - Factor-VIII-Related antigen (VIII R:Ag) is known to be produced by the blood vessel wall. Noxious stimuli increase endothelial release of VIII R:Ag. It might be expected that the development of vasculitis would be associated with increased levels of VIII R:Ag. To investigate this, eight different groups of subjects were studied: 25 patients with systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis (RA) plus vasculitis, 19 with systemic vasculitis and 14 with atherosclerosis. These groups were compared to 29 patients with primary Raynaud's disease, 15 with RA without vasculitis and 50 controls. Results showed that where there was evidence of vascular disease, then VIII R:Ag was elevated. VIII R:Ag appeared to be a more specific marker for vascular damage than erythrocyte sedimentation rate or C-reactive protein. Longitudinal studies in 11 patients showed good correlation between progression of vascular disease and VIII R:Ag.

    AB - Factor-VIII-Related antigen (VIII R:Ag) is known to be produced by the blood vessel wall. Noxious stimuli increase endothelial release of VIII R:Ag. It might be expected that the development of vasculitis would be associated with increased levels of VIII R:Ag. To investigate this, eight different groups of subjects were studied: 25 patients with systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis (RA) plus vasculitis, 19 with systemic vasculitis and 14 with atherosclerosis. These groups were compared to 29 patients with primary Raynaud's disease, 15 with RA without vasculitis and 50 controls. Results showed that where there was evidence of vascular disease, then VIII R:Ag was elevated. VIII R:Ag appeared to be a more specific marker for vascular damage than erythrocyte sedimentation rate or C-reactive protein. Longitudinal studies in 11 patients showed good correlation between progression of vascular disease and VIII R:Ag.

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