Vasoactive intestinal peptide (VIP) induces a K+ current in the Xenopus oocyte membrane

Vincenzina Reale, Michael L. J. Ashford, Eric A. Barnard

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Evidence, based on voltage-clamp and current-clamp recording, is presented for endogenous receptors for vasoactive intestinal polypeptide (VIP) on the cell membrane of the Xenopus oocyte. At normal resting potential a hyperpolarisation is produced by VIP, associated with an increase in K+ conductance. The response is dose-dependent, with a threshold near 10(-9)M VIP. The effect is potentiated by forskolin. Of several other types of neuropeptide tested, only avian pancreatic polypeptide gives a response: this is similar to that of VIP, but this peptide can also potentiate the response to VIP.
    Original languageEnglish
    Pages (from-to)89-94
    Number of pages6
    JournalNeuroscience Letters
    Issue number1-2
    Publication statusPublished - 1987


    • Xenopus laevis
    • Animals
    • Vasoactive Intestinal Peptide
    • Enzyme Activation
    • Ion Channels
    • Cell Membrane
    • Potassium
    • Oocytes
    • Membrane Potentials
    • Adenylate Cyclase
    • Forskolin


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