Vasodilation in black Americans: attenuated nitric oxide-mediated responses

C. Michael Stein, Chim C. Lang, Richard Nelson, Michael Brown, Alastair J. J. Wood

    Research output: Contribution to journalArticlepeer-review

    134 Citations (Scopus)


    Attenuated vasodilation in response to the intra-arterial administration of the beta-adrenergic agonist isoproterenol (INN, isoprenaline), an endothelium-independent vasodilator, has previously been observed in normotensive black Americans. To determine whether this reflected a more generalized attenuation of responses to vasodilators, we compared forearm blood flow responses to the endothelium-dependent vasodilator methacholine and the endothelium-independent vasodilator sodium nitroprusside in young normotensive black men and white men.
    Original languageEnglish
    Pages (from-to)436-443
    Number of pages8
    JournalClinical Pharmacology & Therapeutics
    Issue number4
    Publication statusPublished - Oct 1997


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