TY - JOUR
T1 - Vasodilation in black Americans
T2 - attenuated nitric oxide-mediated responses
AU - Stein, C. Michael
AU - Lang, Chim C.
AU - Nelson, Richard
AU - Brown, Michael
AU - Wood, Alastair J. J.
PY - 1997/10
Y1 - 1997/10
N2 - Attenuated vasodilation in response to the intra-arterial administration of the beta-adrenergic agonist isoproterenol (INN, isoprenaline), an endothelium-independent vasodilator, has previously been observed in normotensive black Americans. To determine whether this reflected a more generalized attenuation of responses to vasodilators, we compared forearm blood flow responses to the endothelium-dependent vasodilator methacholine and the endothelium-independent vasodilator sodium nitroprusside in young normotensive black men and white men.
AB - Attenuated vasodilation in response to the intra-arterial administration of the beta-adrenergic agonist isoproterenol (INN, isoprenaline), an endothelium-independent vasodilator, has previously been observed in normotensive black Americans. To determine whether this reflected a more generalized attenuation of responses to vasodilators, we compared forearm blood flow responses to the endothelium-dependent vasodilator methacholine and the endothelium-independent vasodilator sodium nitroprusside in young normotensive black men and white men.
U2 - 10.1016/S0009-9236(97)90122-3
DO - 10.1016/S0009-9236(97)90122-3
M3 - Article
C2 - 9357395
SN - 0009-9236
VL - 62
SP - 436
EP - 443
JO - Clinical Pharmacology & Therapeutics
JF - Clinical Pharmacology & Therapeutics
IS - 4
ER -