Vasopeptidase inhibitors in heart failure

Adelle Dawson, Allan D Struthers

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Considerable attention has recently focused on the vasopeptidase inhibitors (VPI), a new class of drug that combines angiotensin-converting enzyme (ACE) inhibitor activity with inhibition of natriuretic peptide breakdown. In theory, a drug with these properties may be beneficial both in hypertension and in heart failure. Whilst the efficacy of VPIs in hypertension has been consistently demonstrated in pre-clinical and clinical studies, the role of VPIs, if any, in heart failure is less clear, since numerous small studies have produced conflicting results. Furthermore, preliminary results from the recently completed Omapatrilat Versus Enalapril Randomised Trial of Utility in Reducing Events (OVERTURE) study have failed to establish the VPI, omapatrilat, as a first line therapy in the treatment of chronic heart failure. We review the literature on VPIs in heart failure and discuss possible reasons for the reported lack of benefit over ACE inhibitors.
    Original languageEnglish
    Pages (from-to)156-159
    Number of pages4
    JournalJournal of the Renin-Angiotensin-Aldosterone System : JRAAS
    Volume3
    Issue number3
    DOIs
    Publication statusPublished - 2002

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