Abstract
Direct selective acylation of the primary amino functions of spermine and spermidine with a variety of isolable succinimidyl cinnamates, followed by catalytic hydrogenation, gave high yields of the spermine alkaloid kukoamine A and analogs suitable for structure-activity relationship studies. Suitable succinimidyl cinnamates were readily obtained through Wittig reaction of aromatic aldehydes with the ylides Ph3P=CRCO2Me, followed by saponification and activation with N-hydroxysuccinimide in the presence of N,N'-dicyclohexylcarbodiimide.
Original language | English |
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Pages (from-to) | 264-265 |
Number of pages | 2 |
Journal | Chemistry Letters |
Volume | 34 |
Issue number | 2 |
DOIs | |
Publication status | Published - 5 Feb 2005 |
ASJC Scopus subject areas
- General Chemistry