Villoglandular adenocarcinoma of the cervix: clarity is needed on the histological definition for this difficult diagnosis

R. D.  Macdonald; J.  Kirwan; K.  Hayat; C. S.  Herrington; H.  Shawki

doi:10.1016/j.ygyno.2005.07.133

Villoglandular adenocarcinoma of the cervix: clarity is needed on the histological definition for this difficult diagnosis

R. D. Macdonald, J. Kirwan, K. Hayat, C. S. Herrington, H. Shawki

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23 Citations (Scopus)

Abstract

Background. Villoglandular adenocarcinoma (VGA) of the cervix is
reported as a variant of a cervical adenocarcinoma with a good
prognosis. Cases. We present two cases histologically reported as a
villoglandular adenocarcinoma of the cervix that have recurred and
progressed rapidly since initial treatment. External histopathological
review suggested both had a prominent villoglandular pattern but with an
associated underlying well-differentiated adenocarcinoma. Conclusion.
The diagnosis of VGA is difficult. Current literature is not entirely
consistent in the presented definition, and further clarity is needed.
Because of the rarity of VGA and the difficulty but importance of the
diagnosis, we would feel that a central review of all cases of VGA is
warranted. This would assist in diagnosis and also in obtaining accurate
follow-up data. © 2005 Elsevier Inc. All rights reserved

Original language	English
Pages (from-to)	192-194
Number of pages	3
Journal	Gynecologic Oncology
Volume	100
Issue number	1
DOIs	https://doi.org/10.1016/j.ygyno.2005.07.133
Publication status	Published - 2006

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title = "Villoglandular adenocarcinoma of the cervix: clarity is needed on the histological definition for this difficult diagnosis",

abstract = "Background. Villoglandular adenocarcinoma (VGA) of the cervix is reported as a variant of a cervical adenocarcinoma with a good prognosis. Cases. We present two cases histologically reported as a villoglandular adenocarcinoma of the cervix that have recurred and progressed rapidly since initial treatment. External histopathological review suggested both had a prominent villoglandular pattern but with an associated underlying well-differentiated adenocarcinoma. Conclusion. The diagnosis of VGA is difficult. Current literature is not entirely consistent in the presented definition, and further clarity is needed. Because of the rarity of VGA and the difficulty but importance of the diagnosis, we would feel that a central review of all cases of VGA is warranted. This would assist in diagnosis and also in obtaining accurate follow-up data. {\textcopyright} 2005 Elsevier Inc. All rights reserved",

author = "Macdonald, {R. D.} and J. Kirwan and K. Hayat and Herrington, {C. S.} and H. Shawki",

year = "2006",

doi = "10.1016/j.ygyno.2005.07.133",

language = "English",

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pages = "192--194",

journal = "Gynecologic Oncology",

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TY - JOUR

T1 - Villoglandular adenocarcinoma of the cervix

T2 - clarity is needed on the histological definition for this difficult diagnosis

AU - Macdonald, R. D.

AU - Kirwan, J.

AU - Hayat, K.

AU - Herrington, C. S.

AU - Shawki, H.

PY - 2006

Y1 - 2006

N2 - Background. Villoglandular adenocarcinoma (VGA) of the cervix is reported as a variant of a cervical adenocarcinoma with a good prognosis. Cases. We present two cases histologically reported as a villoglandular adenocarcinoma of the cervix that have recurred and progressed rapidly since initial treatment. External histopathological review suggested both had a prominent villoglandular pattern but with an associated underlying well-differentiated adenocarcinoma. Conclusion. The diagnosis of VGA is difficult. Current literature is not entirely consistent in the presented definition, and further clarity is needed. Because of the rarity of VGA and the difficulty but importance of the diagnosis, we would feel that a central review of all cases of VGA is warranted. This would assist in diagnosis and also in obtaining accurate follow-up data. © 2005 Elsevier Inc. All rights reserved

AB - Background. Villoglandular adenocarcinoma (VGA) of the cervix is reported as a variant of a cervical adenocarcinoma with a good prognosis. Cases. We present two cases histologically reported as a villoglandular adenocarcinoma of the cervix that have recurred and progressed rapidly since initial treatment. External histopathological review suggested both had a prominent villoglandular pattern but with an associated underlying well-differentiated adenocarcinoma. Conclusion. The diagnosis of VGA is difficult. Current literature is not entirely consistent in the presented definition, and further clarity is needed. Because of the rarity of VGA and the difficulty but importance of the diagnosis, we would feel that a central review of all cases of VGA is warranted. This would assist in diagnosis and also in obtaining accurate follow-up data. © 2005 Elsevier Inc. All rights reserved

U2 - 10.1016/j.ygyno.2005.07.133

DO - 10.1016/j.ygyno.2005.07.133

M3 - Article

SN - 0090-8258

VL - 100

SP - 192

EP - 194

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 1

ER -

Villoglandular adenocarcinoma of the cervix: clarity is needed on the histological definition for this difficult diagnosis

Abstract

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