Background. Villoglandular adenocarcinoma (VGA) of the cervix is
reported as a variant of a cervical adenocarcinoma with a good
prognosis. Cases. We present two cases histologically reported as a
villoglandular adenocarcinoma of the cervix that have recurred and
progressed rapidly since initial treatment. External histopathological
review suggested both had a prominent villoglandular pattern but with an
associated underlying well-differentiated adenocarcinoma. Conclusion.
The diagnosis of VGA is difficult. Current literature is not entirely
consistent in the presented definition, and further clarity is needed.
Because of the rarity of VGA and the difficulty but importance of the
diagnosis, we would feel that a central review of all cases of VGA is
warranted. This would assist in diagnosis and also in obtaining accurate
follow-up data. © 2005 Elsevier Inc. All rights reserved