Viral evasion and subversion of pattern-recognition receptor signalling

Andrew G Bowie, Leonie Unterholzner

    Research output: Contribution to journalArticle

    428 Citations (Scopus)

    Abstract

    The expression of pattern-recognition receptors (PRRs) by immune and tissue cells provides the host with the ability to detect and respond to infection by viruses and other microorganisms. Significant progress has been made from studying this area, including the identification of PRRs, such as Toll-like receptors and RIG-I-like receptors, and the description of the molecular basis of their signalling pathways, which lead to the production of interferons and other cytokines. In parallel, common mechanisms used by viruses to evade PRR-mediated responses or to actively subvert these pathways for their own benefit are emerging. Accumulating evidence on how viral infection and PRR signalling pathways intersect is providing further insights into the function of the pathways involved, their constituent proteins and ways in which they could be manipulated therapeutically.
    Original languageEnglish
    Pages (from-to)911-22
    Number of pages12
    JournalNature Reviews Immunology
    Volume8
    Issue number12
    DOIs
    Publication statusPublished - Dec 2008

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