Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

Yilong Zhang; Kanheng Zhou; Zhihong Huang; Chunhui Li

doi:10.1109/IUS52206.2021.9593522

Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

Yilong Zhang, Kanheng Zhou, Zhihong Huang, Chunhui Li

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test.

Original language	English
Title of host publication	IEEE International Ultrasonics Symposium, IUS
Publisher	IEEE
Pages	1-4
Number of pages	4
ISBN (Electronic)	9780738112091
DOIs	https://doi.org/10.1109/IUS52206.2021.9593522
Publication status	Published - Sept 2021
Event	2021 IEEE International Ultrasonics Symposium, IUS 2021 - Virtual, Online, China Duration: 11 Sept 2011 → 16 Sept 2011

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
Publisher	Institute of Electrical and Electronics Engineers
ISSN (Print)	1948-5719

Conference

Conference	2021 IEEE International Ultrasonics Symposium, IUS 2021
Country/Territory	China
City	Virtual, Online
Period	11/09/11 → 16/09/11

Keywords

air-pulse system
corneal stromal model
optical coherence elastography (OCE)
surface acoustic wave (SAW)
viscoelastic properties

ASJC Scopus subject areas

Acoustics and Ultrasonics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/IUS52206.2021.9593522

Cite this

@inproceedings{5502102faf234c45b2147a663fe7956c,

title = "Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)",

abstract = "viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test. ",

keywords = "air-pulse system, corneal stromal model, optical coherence elastography (OCE), surface acoustic wave (SAW), viscoelastic properties",

author = "Yilong Zhang and Kanheng Zhou and Zhihong Huang and Chunhui Li",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 2021 IEEE International Ultrasonics Symposium, IUS 2021 ; Conference date: 11-09-2011 Through 16-09-2011",

year = "2021",

month = sep,

doi = "10.1109/IUS52206.2021.9593522",

language = "English",

series = "IEEE International Ultrasonics Symposium, IUS",

publisher = "IEEE",

pages = "1--4",

booktitle = "IEEE International Ultrasonics Symposium, IUS",

}

Zhang, Y, Zhou, K, Huang, Z & Li, C 2021, Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE). in IEEE International Ultrasonics Symposium, IUS. IEEE International Ultrasonics Symposium, IUS, IEEE, pp. 1-4, 2021 IEEE International Ultrasonics Symposium, IUS 2021, Virtual, Online, China, 11/09/11. https://doi.org/10.1109/IUS52206.2021.9593522

Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE). / Zhang, Yilong; Zhou, Kanheng; Huang, Zhihong et al.
IEEE International Ultrasonics Symposium, IUS. IEEE, 2021. p. 1-4 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

AU - Zhang, Yilong

AU - Zhou, Kanheng

AU - Huang, Zhihong

AU - Li, Chunhui

PY - 2021/9

Y1 - 2021/9

N2 - viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test.

AB - viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test.

KW - air-pulse system

KW - corneal stromal model

KW - optical coherence elastography (OCE)

KW - surface acoustic wave (SAW)

KW - viscoelastic properties

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U2 - 10.1109/IUS52206.2021.9593522

DO - 10.1109/IUS52206.2021.9593522

M3 - Conference contribution

AN - SCOPUS:85122874945

T3 - IEEE International Ultrasonics Symposium, IUS

SP - 1

EP - 4

BT - IEEE International Ultrasonics Symposium, IUS

PB - IEEE

T2 - 2021 IEEE International Ultrasonics Symposium, IUS 2021

Y2 - 11 September 2011 through 16 September 2011

ER -

Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Fingerprint

Characterising Viscoelastic Properties of Corneal Stromal Models with Optical Coherence Elastography

Cite this

Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Student theses

Characterising Viscoelastic Properties of Corneal Stromal Models with Optical Coherence Elastography

Cite this