Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

TY - GEN

T1 - Viscoelastic properties of a corneal stromal model measured by surface acoustic wave optical coherence elastography (SAW-OCE)

AU - Zhang, Yilong

AU - Zhou, Kanheng

AU - Huang, Zhihong

AU - Li, Chunhui

N1 - Publisher Copyright: © 2021 IEEE.

PY - 2021/9

Y1 - 2021/9

N2 - viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test.

AB - viscoelastic properties of the cornea are mainly provided by the stromal layer, acting as the important parameters to diagnose corneal diseases and access the effectiveness of surgery and treatment. In this study, collagen-based hydrogels incorporated with keratocytes were reconstructed to mimic the human cornea stroma. An air-pulse-based surface acoustic wave optical coherence elastography (SAW-OCE) was used to examine the changes in the viscoelastic properties of the hydrogels with different initial collagen concentrations of 3, 5, 7 mg/ml over 7 days. The results showed that the hydrogels with a lower initial collagen concentration had a greater increase in the elastic modulus and the viscosity with the culturing time. Moreover, the SAW-OCE estimated viscoelasticity of the no cell hydrogels on day 1 was validated with the outcomes from plate compression, ramp-hold relaxation test.

KW - air-pulse system

KW - corneal stromal model

KW - optical coherence elastography (OCE)

KW - surface acoustic wave (SAW)

KW - viscoelastic properties

UR - https://www.scopus.com/pages/publications/85122874945

U2 - 10.1109/IUS52206.2021.9593522

DO - 10.1109/IUS52206.2021.9593522

M3 - Conference contribution

AN - SCOPUS:85122874945

T3 - IEEE International Ultrasonics Symposium, IUS

SP - 1

EP - 4

BT - IEEE International Ultrasonics Symposium, IUS

PB - IEEE

T2 - 2021 IEEE International Ultrasonics Symposium, IUS 2021

Y2 - 11 September 2011 through 16 September 2011

ER -