Visualization of multiple alignments, phylogenies and gene family evolution

James B. Procter, Julie Thompson, Ivica Letunic, Chris Creevey, Fabrice Jossinet, Geoffrey J. Barton

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

Software for visualizing sequence alignments and trees are essential tools for life scientists. In this review, we describe the major features and capabilities of a selection of stand-alone and web-based applications useful when investigating the function and evolution of a gene family. These range from simple viewers, to systems that provide sophisticated editing and analysis functions. We conclude with a discussion of the challenges that these tools now face due to the flood of next generation sequence data and the increasingly complex network of bioinformatics information sources.

Original languageEnglish
Pages (from-to)S16-S25
Number of pages10
JournalNature Methods
Volume7
Issue number3
DOIs
Publication statusPublished - 1 Mar 2010

Keywords

  • SEQUENCE ALIGNMENT
  • RESIDUE CONSERVATION
  • HYPERBOLIC SPACE
  • TREES
  • DATABASE
  • INFORMATION
  • ONTOLOGY
  • DISPLAY
  • TOOL
  • PREDICTION

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