Visualizing choriocapillaris using swept source optical coherence tomography angiography with various probe beam sizes

Kanheng Zhou, Shaozhen Song, Qinqin Zhang, Zhongdi Chu, Zhihong Huang, Ruikang K. Wang (Lead / Corresponding author)

Research output: Contribution to journalArticle

1 Citation (Scopus)
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Abstract

Imaging choriocapillaris (CC) is a long-term challenge for commercial OCT angiography (OCTA) systems due to limited transverse resolution. Effects of transverse resolution on the visualization of a CC microvascular network are explored and demonstrated in this paper. We use three probe beams with sizes of ~1.12 mm, ~2.51 mm and ~3.50 mm at the pupil plane, which deliver an estimated transverse resolution at the retina of 17.5 µm, 8.8 µm and 7.0 µm, respectively, to investigate the ability of OCTA to resolve the CC capillary vessels. The complex optical microangiography algorithm is applied to extract blood flow in the CC slab. Mean retinal pigment epithelium (RPE) to CC (RPE-CC) distance, mean CC inter-vascular spacing and the magnitude in the radially-averaged power spectrum are quantified. We demonstrate that a clearer CC lobular capillary network is resolved in the angiograms provided by a larger beam size. The image contrast of the CC angiogram with a large beam size of 3.50 mm is 114% higher than that with a small beam size of 1.12 mm. While the measurements of the mean RPE-CC distance and CC inter-vascular spacing are almost consistent regardless of the beam sizes, they are more reliable and stable with the larger beam size of 3.50 mm. We conclude that the beam size is a key parameter for CC angiography if the purpose of the investigation is to visualize the individual CC capillaries.

Original languageEnglish
Pages (from-to)2847-2860
Number of pages14
JournalBiomedical Optics Express
Volume10
Issue number6
Early online date16 May 2019
DOIs
Publication statusPublished - 1 Jun 2019

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angiography
Optical Coherence Tomography
Angiography
tomography
probes
Retinal Pigment Epithelium
Blood Vessels
epithelium
pigments
spacing
Pupil
Microvessels
Retina
retina
image contrast
pupils
blood flow
vessels
power spectra
slabs

Cite this

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title = "Visualizing choriocapillaris using swept source optical coherence tomography angiography with various probe beam sizes",
abstract = "Imaging choriocapillaris (CC) is a long-term challenge for commercial OCT angiography (OCTA) systems due to limited transverse resolution. Effects of transverse resolution on the visualization of a CC microvascular network are explored and demonstrated in this paper. We use three probe beams with sizes of ~1.12 mm, ~2.51 mm and ~3.50 mm at the pupil plane, which deliver an estimated transverse resolution at the retina of 17.5 µm, 8.8 µm and 7.0 µm, respectively, to investigate the ability of OCTA to resolve the CC capillary vessels. The complex optical microangiography algorithm is applied to extract blood flow in the CC slab. Mean retinal pigment epithelium (RPE) to CC (RPE-CC) distance, mean CC inter-vascular spacing and the magnitude in the radially-averaged power spectrum are quantified. We demonstrate that a clearer CC lobular capillary network is resolved in the angiograms provided by a larger beam size. The image contrast of the CC angiogram with a large beam size of 3.50 mm is 114{\%} higher than that with a small beam size of 1.12 mm. While the measurements of the mean RPE-CC distance and CC inter-vascular spacing are almost consistent regardless of the beam sizes, they are more reliable and stable with the larger beam size of 3.50 mm. We conclude that the beam size is a key parameter for CC angiography if the purpose of the investigation is to visualize the individual CC capillaries.",
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Visualizing choriocapillaris using swept source optical coherence tomography angiography with various probe beam sizes. / Zhou, Kanheng; Song, Shaozhen; Zhang, Qinqin; Chu, Zhongdi; Huang, Zhihong; Wang, Ruikang K. (Lead / Corresponding author).

In: Biomedical Optics Express, Vol. 10, No. 6, 01.06.2019, p. 2847-2860.

Research output: Contribution to journalArticle

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AU - Song, Shaozhen

AU - Zhang, Qinqin

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