Ways to unwind with HROB, a new player in homologous recombination

Giulia Saredi, John Rouse (Lead / Corresponding author)

Research output: Contribution to journalReview article

Abstract

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

Original languageEnglish
Pages (from-to)1293-1294
Number of pages2
JournalGenes & Development
Volume33
Issue number19-20
DOIs
Publication statusPublished - 1 Oct 2019

Fingerprint

Homologous Recombination
DNA Repair
Minichromosome Maintenance Proteins
Double-Stranded DNA Breaks
DNA
Genes

Keywords

  • CRISPR screens
  • cisplatin
  • DNA damage
  • DNA repair
  • DNA synthesis
  • germ cells
  • helicase
  • homologous recombination
  • infertility

Cite this

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title = "Ways to unwind with HROB, a new player in homologous recombination",
abstract = "Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.",
keywords = "CRISPR screens, cisplatin, DNA damage, DNA repair, DNA synthesis, germ cells, helicase, homologous recombination, infertility",
author = "Giulia Saredi and John Rouse",
note = "G.S. is supported by an EMBO Long-Term Postdoctoral Fellowship (ALTF 951-2018). Work in the Rouse laboratory is funded by the Medical Research Council (grant no. MC_UU_12016/1).",
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Ways to unwind with HROB, a new player in homologous recombination. / Saredi, Giulia; Rouse, John (Lead / Corresponding author).

In: Genes & Development, Vol. 33, No. 19-20, 01.10.2019, p. 1293-1294.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Ways to unwind with HROB, a new player in homologous recombination

AU - Saredi, Giulia

AU - Rouse, John

N1 - G.S. is supported by an EMBO Long-Term Postdoctoral Fellowship (ALTF 951-2018). Work in the Rouse laboratory is funded by the Medical Research Council (grant no. MC_UU_12016/1).

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

AB - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

KW - CRISPR screens

KW - cisplatin

KW - DNA damage

KW - DNA repair

KW - DNA synthesis

KW - germ cells

KW - helicase

KW - homologous recombination

KW - infertility

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M3 - Review article

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