Abstract
Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 1293-1294 |
| Number of pages | 2 |
| Journal | Genes & Development |
| Volume | 33 |
| Issue number | 19-20 |
| DOIs | |
| Publication status | Published - 1 Oct 2019 |
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Keywords
- CRISPR screens
- cisplatin
- DNA damage
- DNA repair
- DNA synthesis
- germ cells
- helicase
- homologous recombination
- infertility
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Ways to unwind with HROB, a new player in homologous recombination. / Saredi, Giulia; Rouse, John (Lead / Corresponding author).
In: Genes & Development, Vol. 33, No. 19-20, 01.10.2019, p. 1293-1294.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Ways to unwind with HROB, a new player in homologous recombination
AU - Saredi, Giulia
AU - Rouse, John
N1 - G.S. is supported by an EMBO Long-Term Postdoctoral Fellowship (ALTF 951-2018). Work in the Rouse laboratory is funded by the Medical Research Council (grant no. MC_UU_12016/1).
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.
AB - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.
KW - CRISPR screens
KW - cisplatin
KW - DNA damage
KW - DNA repair
KW - DNA synthesis
KW - germ cells
KW - helicase
KW - homologous recombination
KW - infertility
U2 - 10.1101/gad.331850.119
DO - 10.1101/gad.331850.119
M3 - Review article
C2 - 31575675
VL - 33
SP - 1293
EP - 1294
JO - Genes & Development
JF - Genes & Development
SN - 0890-9369
IS - 19-20
ER -