Ways to unwind with HROB, a new player in homologous recombination

Giulia Saredi, John Rouse (Lead / Corresponding author)

Research output: Contribution to journalReview article

1 Citation (Scopus)
21 Downloads (Pure)

Abstract

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

Original languageEnglish
Pages (from-to)1293-1294
Number of pages2
JournalGenes & Development
Volume33
Issue number19-20
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • CRISPR screens
  • cisplatin
  • DNA damage
  • DNA repair
  • DNA synthesis
  • germ cells
  • helicase
  • homologous recombination
  • infertility
  • Infertility]
  • Helicase
  • Germ cells
  • Homologous recombination
  • Cisplatin

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