Ways to unwind with HROB, a new player in homologous recombination

Giulia Saredi; John Rouse

doi:10.1101/gad.331850.119

Ways to unwind with HROB, a new player in homologous recombination

Giulia Saredi, John Rouse (Lead / Corresponding author)

MRC PPU

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Abstract

Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

Original language	English
Pages (from-to)	1293-1294
Number of pages	2
Journal	Genes & Development
Volume	33
Issue number	19-20
DOIs	https://doi.org/10.1101/gad.331850.119
Publication status	Published - 1 Oct 2019

Keywords

CRISPR screens
cisplatin
DNA damage
DNA repair
DNA synthesis
germ cells
helicase
homologous recombination
infertility
Infertility]
Helicase
Germ cells
Homologous recombination
Cisplatin

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10.1101/gad.331850.119

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This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
Final published version, 248 KBLicence: CC BY-NC

Cite this

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title = "Ways to unwind with HROB, a new player in homologous recombination",

abstract = "Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.",

keywords = "CRISPR screens, cisplatin, DNA damage, DNA repair, DNA synthesis, germ cells, helicase, homologous recombination, infertility, Infertility], Helicase, Germ cells, Homologous recombination, Cisplatin",

author = "Giulia Saredi and John Rouse",

note = "G.S. is supported by an EMBO Long-Term Postdoctoral Fellowship (ALTF 951-2018). Work in the Rouse laboratory is funded by the Medical Research Council (grant no. MC_UU_12016/1).",

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AU - Saredi, Giulia

AU - Rouse, John

N1 - G.S. is supported by an EMBO Long-Term Postdoctoral Fellowship (ALTF 951-2018). Work in the Rouse laboratory is funded by the Medical Research Council (grant no. MC_UU_12016/1).

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

AB - Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397-1415) reveal HROB as a new player in HR required for recruitment of the MCM8-9 complex, which is paralogous to the MCM2-7 replicative helicase. HROB functions closely with MCM8-9 to promote postsynaptic DNA repair synthesis. This study sheds valuable light on late events in HR and suggests that HROB may load MCM8-9 onto HR intermediates to facilitate the DNA unwinding required for DNA repair synthesis.

KW - CRISPR screens

KW - cisplatin

KW - DNA damage

KW - DNA repair

KW - DNA synthesis

KW - germ cells

KW - helicase

KW - homologous recombination

KW - infertility

KW - Infertility]

KW - Helicase

KW - Germ cells

KW - Homologous recombination

KW - Cisplatin

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JO - Genes & Development

JF - Genes & Development

SN - 0890-9369

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ER -

Ways to unwind with HROB, a new player in homologous recombination

Abstract

Keywords

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