Abstract
Introduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays, including apoptosis, senescence, and regeneration.
Area covered: Here, we summarise the p53 isoforms and their relevance to cancer to establish an understanding and theorise on potential applications of the isoforms in clinical practice.
Expert commentary: Pertaining to the different expression of isoforms in different tumors, it is concluded that the clinical use of isoforms as prognostic and predictive biomarkers will be different depending on the cell type, the tissue origin of the tumors, the position of the TP53 mutation and the driver-oncogene.
| Original language | English |
|---|---|
| Pages (from-to) | 149-159 |
| Number of pages | 11 |
| Journal | Expert Review of Molecular Diagnostics |
| Volume | 19 |
| Issue number | 2 |
| Early online date | 7 Jan 2019 |
| DOIs | |
| Publication status | Published - Feb 2019 |
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Keywords
- Apoptosis
- biomarker
- cancer
- p53
- p53 isoforms
- tumour
Cite this
}
What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer? / Hayman, Liam; Chaudhry, Wajeeh Raza; Revin, Victor V.; Zhelev, Nikolai; Bourdon, Jean-Christophe (Lead / Corresponding author).
In: Expert Review of Molecular Diagnostics, Vol. 19, No. 2, 02.2019, p. 149-159.Research output: Contribution to journal › Review article
TY - JOUR
T1 - What is the potential of p53 isoforms as a predictive biomarker in the treatment of cancer?
AU - Hayman, Liam
AU - Chaudhry, Wajeeh Raza
AU - Revin, Victor V.
AU - Zhelev, Nikolai
AU - Bourdon, Jean-Christophe
N1 - No funding.
PY - 2019/2
Y1 - 2019/2
N2 - Introduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays, including apoptosis, senescence, and regeneration. Area covered: Here, we summarise the p53 isoforms and their relevance to cancer to establish an understanding and theorise on potential applications of the isoforms in clinical practice. Expert commentary: Pertaining to the different expression of isoforms in different tumors, it is concluded that the clinical use of isoforms as prognostic and predictive biomarkers will be different depending on the cell type, the tissue origin of the tumors, the position of the TP53 mutation and the driver-oncogene.
AB - Introduction: For decades, p53 was researched as a single protein with alterations described as mutants. The discovery of 12 human p53 isoforms expressed from 9 transcripts changed this perception, eloquently explaining the numerous roles p53 plays, including apoptosis, senescence, and regeneration. Area covered: Here, we summarise the p53 isoforms and their relevance to cancer to establish an understanding and theorise on potential applications of the isoforms in clinical practice. Expert commentary: Pertaining to the different expression of isoforms in different tumors, it is concluded that the clinical use of isoforms as prognostic and predictive biomarkers will be different depending on the cell type, the tissue origin of the tumors, the position of the TP53 mutation and the driver-oncogene.
KW - Apoptosis
KW - biomarker
KW - cancer
KW - p53
KW - p53 isoforms
KW - tumour
UR - http://www.scopus.com/inward/record.url?scp=85061086054&partnerID=8YFLogxK
U2 - 10.1080/14737159.2019.1563484
DO - 10.1080/14737159.2019.1563484
M3 - Review article
C2 - 30582376
VL - 19
SP - 149
EP - 159
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
SN - 1473-7159
IS - 2
ER -