What Lies Beneath? Scanning Probe Tomography May Have the Answer

    Research output: Contribution to journalComment/debate

    1 Citation (Scopus)

    Abstract

    Scanning probe microscopy facilitates high-resolution noninvasive imaging of surface topography on even the most delicate of biological structures. Moreover, the local probe nature of the instrument architecture lends itself to the measurement of many important physical properties. To date, biological investigations have largely been constrained to imaging surface (membrane)-borne phenomena; however, the advent of extremely high aspect-ratio 'needle' probe tips, as reported by Beard et al. (2013), suggests that the approach can now be extended to address the particular challenges associated with measuring subsurface microscopic targets, including the intracellular components of the stratum corneum.
    Original languageEnglish
    Pages (from-to)1458-1460
    Number of pages3
    JournalJournal of Investigative Dermatology
    Volume133
    Issue number6
    DOIs
    Publication statusPublished - 2013

    Fingerprint

    Scanning Probe Microscopy
    Cornea
    Needles
    Tomography
    Scanning
    Imaging techniques
    Scanning probe microscopy
    Membranes
    Surface topography
    Aspect ratio
    Physical properties

    Keywords

    • ATOMIC-FORCE MICROSCOPY

    Cite this

    @article{868962c33307420593980609e1c088d9,
    title = "What Lies Beneath? Scanning Probe Tomography May Have the Answer",
    abstract = "Scanning probe microscopy facilitates high-resolution noninvasive imaging of surface topography on even the most delicate of biological structures. Moreover, the local probe nature of the instrument architecture lends itself to the measurement of many important physical properties. To date, biological investigations have largely been constrained to imaging surface (membrane)-borne phenomena; however, the advent of extremely high aspect-ratio 'needle' probe tips, as reported by Beard et al. (2013), suggests that the approach can now be extended to address the particular challenges associated with measuring subsurface microscopic targets, including the intracellular components of the stratum corneum.",
    keywords = "ATOMIC-FORCE MICROSCOPY",
    author = "Conneely, {Michael J.} and Campbell, {Paul A}",
    year = "2013",
    doi = "10.1038/jid.2013.30",
    language = "English",
    volume = "133",
    pages = "1458--1460",
    journal = "Journal of Investigative Dermatology",
    issn = "0022-202X",
    publisher = "Nature Publishing Group",
    number = "6",

    }

    What Lies Beneath? Scanning Probe Tomography May Have the Answer. / Conneely, Michael J.; Campbell, Paul A.

    In: Journal of Investigative Dermatology, Vol. 133, No. 6, 2013, p. 1458-1460.

    Research output: Contribution to journalComment/debate

    TY - JOUR

    T1 - What Lies Beneath? Scanning Probe Tomography May Have the Answer

    AU - Conneely, Michael J.

    AU - Campbell, Paul A

    PY - 2013

    Y1 - 2013

    N2 - Scanning probe microscopy facilitates high-resolution noninvasive imaging of surface topography on even the most delicate of biological structures. Moreover, the local probe nature of the instrument architecture lends itself to the measurement of many important physical properties. To date, biological investigations have largely been constrained to imaging surface (membrane)-borne phenomena; however, the advent of extremely high aspect-ratio 'needle' probe tips, as reported by Beard et al. (2013), suggests that the approach can now be extended to address the particular challenges associated with measuring subsurface microscopic targets, including the intracellular components of the stratum corneum.

    AB - Scanning probe microscopy facilitates high-resolution noninvasive imaging of surface topography on even the most delicate of biological structures. Moreover, the local probe nature of the instrument architecture lends itself to the measurement of many important physical properties. To date, biological investigations have largely been constrained to imaging surface (membrane)-borne phenomena; however, the advent of extremely high aspect-ratio 'needle' probe tips, as reported by Beard et al. (2013), suggests that the approach can now be extended to address the particular challenges associated with measuring subsurface microscopic targets, including the intracellular components of the stratum corneum.

    KW - ATOMIC-FORCE MICROSCOPY

    U2 - 10.1038/jid.2013.30

    DO - 10.1038/jid.2013.30

    M3 - Comment/debate

    C2 - 23673500

    VL - 133

    SP - 1458

    EP - 1460

    JO - Journal of Investigative Dermatology

    JF - Journal of Investigative Dermatology

    SN - 0022-202X

    IS - 6

    ER -