What should it take to describe a substance or product as 'sperm-safe'

David Mortimer, Christopher L R Barratt, Lars Björndahl, Christiaan de Jager, Anne M Jequier, Charles H Muller

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    BACKGROUND: Male reproductive potential continues to be adversely affected by many environmental, industrial and pharmaceutical toxins. Pre-emptive testing for reproductive toxicological (side-)effects remains limited, or even non-existent. Many products that come into direct contact with spermatozoa lack adequate testing for the absence of adverse effects, and numerous products that are intended for exposure to spermatozoa have only a general assumption of safety based on the absence of evidence of actual harm. Such assumptions can have unfortunate adverse impacts on at-risk individuals (e.g. couples who are trying to conceive), illustrating a clear need for appropriate up-front testing to establish actual 'sperm safety'.

    METHODS: After compiling a list of general areas within the review's scope, relevant literature and other information was obtained from the authors' personal professional libraries and archives, and supplemented as necessary using PubMed and Google searches. Review by co-authors identified and eliminated errors of omission or bias.

    RESULTS: This review provides an overview of the broad range of substances, materials and products that can affect male fertility, especially through sperm fertilizing ability, along with a discussion of practical methods and bioassays for their evaluation. It is concluded that products can only be claimed to be 'sperm-safe' after performing objective, properly designed experimental studies; extrapolation from supposed predicate products or other assumptions cannot be trusted.

    CONCLUSIONS: We call for adopting the precautionary principle, especially when exposure to a product might affect not only a couple's fertility potential but also the health of resulting offspring and perhaps future generations.

    Original languageEnglish
    Pages (from-to)i1-i45
    Number of pages45
    JournalHuman Reproduction Update
    Volume19
    Issue numberSUPPL1
    DOIs
    Publication statusPublished - Apr 2013

    Fingerprint

    Spermatozoa
    Fertility
    Safety
    Aptitude
    Social Responsibility
    PubMed
    Biological Assay
    Toxicology
    Libraries
    Health
    Pharmaceutical Preparations

    Keywords

    • Environmental Exposure
    • Environmental Pollutants/toxicity
    • Fertility/drug effects
    • Humans
    • Infertility, Male/chemically induced
    • Male
    • Safety
    • Sperm Count
    • Sperm Motility/drug effects
    • Spermatozoa/cytology
    • Toxicity Tests
    • Xenobiotics/toxicity

    Cite this

    Mortimer, David ; Barratt, Christopher L R ; Björndahl, Lars ; de Jager, Christiaan ; Jequier, Anne M ; Muller, Charles H. / What should it take to describe a substance or product as 'sperm-safe'. In: Human Reproduction Update. 2013 ; Vol. 19, No. SUPPL1. pp. i1-i45.
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    title = "What should it take to describe a substance or product as 'sperm-safe'",
    abstract = "BACKGROUND: Male reproductive potential continues to be adversely affected by many environmental, industrial and pharmaceutical toxins. Pre-emptive testing for reproductive toxicological (side-)effects remains limited, or even non-existent. Many products that come into direct contact with spermatozoa lack adequate testing for the absence of adverse effects, and numerous products that are intended for exposure to spermatozoa have only a general assumption of safety based on the absence of evidence of actual harm. Such assumptions can have unfortunate adverse impacts on at-risk individuals (e.g. couples who are trying to conceive), illustrating a clear need for appropriate up-front testing to establish actual 'sperm safety'.METHODS: After compiling a list of general areas within the review's scope, relevant literature and other information was obtained from the authors' personal professional libraries and archives, and supplemented as necessary using PubMed and Google searches. Review by co-authors identified and eliminated errors of omission or bias.RESULTS: This review provides an overview of the broad range of substances, materials and products that can affect male fertility, especially through sperm fertilizing ability, along with a discussion of practical methods and bioassays for their evaluation. It is concluded that products can only be claimed to be 'sperm-safe' after performing objective, properly designed experimental studies; extrapolation from supposed predicate products or other assumptions cannot be trusted.CONCLUSIONS: We call for adopting the precautionary principle, especially when exposure to a product might affect not only a couple's fertility potential but also the health of resulting offspring and perhaps future generations.",
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    What should it take to describe a substance or product as 'sperm-safe'. / Mortimer, David; Barratt, Christopher L R; Björndahl, Lars; de Jager, Christiaan; Jequier, Anne M; Muller, Charles H.

    In: Human Reproduction Update, Vol. 19, No. SUPPL1, 04.2013, p. i1-i45.

    Research output: Contribution to journalArticle

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    T1 - What should it take to describe a substance or product as 'sperm-safe'

    AU - Mortimer, David

    AU - Barratt, Christopher L R

    AU - Björndahl, Lars

    AU - de Jager, Christiaan

    AU - Jequier, Anne M

    AU - Muller, Charles H

    N1 - Copyright 2013 Elsevier B.V., All rights reserved.

    PY - 2013/4

    Y1 - 2013/4

    N2 - BACKGROUND: Male reproductive potential continues to be adversely affected by many environmental, industrial and pharmaceutical toxins. Pre-emptive testing for reproductive toxicological (side-)effects remains limited, or even non-existent. Many products that come into direct contact with spermatozoa lack adequate testing for the absence of adverse effects, and numerous products that are intended for exposure to spermatozoa have only a general assumption of safety based on the absence of evidence of actual harm. Such assumptions can have unfortunate adverse impacts on at-risk individuals (e.g. couples who are trying to conceive), illustrating a clear need for appropriate up-front testing to establish actual 'sperm safety'.METHODS: After compiling a list of general areas within the review's scope, relevant literature and other information was obtained from the authors' personal professional libraries and archives, and supplemented as necessary using PubMed and Google searches. Review by co-authors identified and eliminated errors of omission or bias.RESULTS: This review provides an overview of the broad range of substances, materials and products that can affect male fertility, especially through sperm fertilizing ability, along with a discussion of practical methods and bioassays for their evaluation. It is concluded that products can only be claimed to be 'sperm-safe' after performing objective, properly designed experimental studies; extrapolation from supposed predicate products or other assumptions cannot be trusted.CONCLUSIONS: We call for adopting the precautionary principle, especially when exposure to a product might affect not only a couple's fertility potential but also the health of resulting offspring and perhaps future generations.

    AB - BACKGROUND: Male reproductive potential continues to be adversely affected by many environmental, industrial and pharmaceutical toxins. Pre-emptive testing for reproductive toxicological (side-)effects remains limited, or even non-existent. Many products that come into direct contact with spermatozoa lack adequate testing for the absence of adverse effects, and numerous products that are intended for exposure to spermatozoa have only a general assumption of safety based on the absence of evidence of actual harm. Such assumptions can have unfortunate adverse impacts on at-risk individuals (e.g. couples who are trying to conceive), illustrating a clear need for appropriate up-front testing to establish actual 'sperm safety'.METHODS: After compiling a list of general areas within the review's scope, relevant literature and other information was obtained from the authors' personal professional libraries and archives, and supplemented as necessary using PubMed and Google searches. Review by co-authors identified and eliminated errors of omission or bias.RESULTS: This review provides an overview of the broad range of substances, materials and products that can affect male fertility, especially through sperm fertilizing ability, along with a discussion of practical methods and bioassays for their evaluation. It is concluded that products can only be claimed to be 'sperm-safe' after performing objective, properly designed experimental studies; extrapolation from supposed predicate products or other assumptions cannot be trusted.CONCLUSIONS: We call for adopting the precautionary principle, especially when exposure to a product might affect not only a couple's fertility potential but also the health of resulting offspring and perhaps future generations.

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    KW - Safety

    KW - Sperm Count

    KW - Sperm Motility/drug effects

    KW - Spermatozoa/cytology

    KW - Toxicity Tests

    KW - Xenobiotics/toxicity

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    JO - Human Reproduction Update

    JF - Human Reproduction Update

    SN - 1355-4786

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