Where does asymmetry come from? Illustrating principles of polarity and asymmetry establishment in Drosophila neuroblasts

Nicolas Loyer, Jens Januschke (Lead / Corresponding author)

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Asymmetric cell division (ACD) is the fundamental process through which one cell divides into two cells with different fates. In animals, it is crucial for the generation of cell-type diversity and for stem cells, which use ACD both to self-renew and produce one differentiating daughter cell. One of the most prominent model systems of ACD, Drosophila neuroblasts, relies on the PAR complex, a conserved set of proteins governing cell polarity in animals. Here, we focus on recent advances in our understanding of the mechanisms that control the orientation of the neuroblast polarity axis, how the PAR complex is positioned, and how its activity may regulate division orientation and cell fate determinant localization and discuss how important findings about the composition polarity complexes in other models may apply to neuroblasts.

Original languageEnglish
Pages (from-to)70-77
Number of pages8
JournalCurrent Opinion in Cell Biology
Early online date4 Nov 2019
Publication statusPublished - Feb 2020



  • Asymmetric cell division
  • Cell polarity
  • Drosophila
  • Neuroblasts

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