Whole blood granulocyte aggregation in vitro in dialysis-dependent patients

J. E. Taylor, A. Bridges, I. S. Henderson, W. K. Stewart, J. J. F. Belch

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    4 Citations (Scopus)

    Abstract

    Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.
    Original languageEnglish
    Pages (from-to)765-769
    Number of pages5
    JournalBlood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
    Volume2
    Issue number6
    Publication statusPublished - Dec 1991

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