Whole blood granulocyte aggregation in vitro in dialysis-dependent patients

J. E. Taylor, A. Bridges, I. S. Henderson, W. K. Stewart, J. J. F. Belch

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    3 Citations (Scopus)

    Abstract

    Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.
    Original languageEnglish
    Pages (from-to)765-769
    Number of pages5
    JournalBlood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
    Volume2
    Issue number6
    Publication statusPublished - Dec 1991

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    Granulocytes
    Dialysis
    Continuous Ambulatory Peritoneal Dialysis
    Renal Dialysis
    In Vitro Techniques
    Vascular Diseases
    Morbidity

    Cite this

    @article{8c1226b7ea8943cbac7db128874cc83f,
    title = "Whole blood granulocyte aggregation in vitro in dialysis-dependent patients",
    abstract = "Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71){\%}; HD patients: 53.0 (32-67){\%}; Controls; 42.5 (33-56){\%}.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.",
    author = "Taylor, {J. E.} and A. Bridges and Henderson, {I. S.} and Stewart, {W. K.} and Belch, {J. J. F.}",
    year = "1991",
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    journal = "Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis",
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    Whole blood granulocyte aggregation in vitro in dialysis-dependent patients. / Taylor, J. E.; Bridges, A.; Henderson, I. S.; Stewart, W. K.; Belch, J. J. F.

    In: Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, Vol. 2, No. 6, 12.1991, p. 765-769.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Whole blood granulocyte aggregation in vitro in dialysis-dependent patients

    AU - Taylor, J. E.

    AU - Bridges, A.

    AU - Henderson, I. S.

    AU - Stewart, W. K.

    AU - Belch, J. J. F.

    PY - 1991/12

    Y1 - 1991/12

    N2 - Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.

    AB - Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.

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    VL - 2

    SP - 765

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    JO - Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis

    JF - Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis

    SN - 0957-5235

    IS - 6

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