Whole blood granulocyte aggregation in vitro in dialysis-dependent patients

TY - JOUR

T1 - Whole blood granulocyte aggregation in vitro in dialysis-dependent patients

AU - Taylor, J. E.

AU - Bridges, A.

AU - Henderson, I. S.

AU - Stewart, W. K.

AU - Belch, J. J. F.

PY - 1991/12

Y1 - 1991/12

N2 - Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.

AB - Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.

M3 - Article

C2 - 1799663

SN - 0957-5235

VL - 2

SP - 765

EP - 769

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

IS - 6

ER -