Whole blood granulocyte aggregation in vitro was measured in 17 haemodialysis (HD) patients, 18 continuous ambulatory peritoneal dialysis (CAPD) patients, and 30 age-matched normal controls. Granulocyte aggregation was significantly increased in dialysis-dependent patients compared to controls (P < 0.001) and was statistically significantly higher in CAPD patients compared to HD patients (P < 0.01). [CAPD patients, median (range): 56.5 (44-71)%; HD patients: 53.0 (32-67)%; Controls; 42.5 (33-56)%.] Since granulocyte hyperaggregability has been linked with the pathogenesis of ischaemic vascular disease, abnormal granulocyte activity in dialysis-dependent patients may be of many factors contributing to their increased cardiovascular morbidity.
|Number of pages||5|
|Journal||Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis|
|Publication status||Published - Dec 1991|
Taylor, J. E., Bridges, A., Henderson, I. S., Stewart, W. K., & Belch, J. J. F. (1991). Whole blood granulocyte aggregation in vitro in dialysis-dependent patients. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 2(6), 765-769. http://journals.lww.com/bloodcoagulation/Abstract/1991/12000/Whole_blood_granulocyte_aggregation_in_vitro_in.11.aspx