Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease

Jonathan R. Weir-McCall (Lead / Corresponding author), Suzanne L. Duce, Stephen J. Gandy, Shona Z. Matthew, Patricia Martin, Deirdre B. Cassidy, Lynne McCormick, Jill J F Belch, Allan D. Struthers, Helen M. Colhoun, J. Graeme Houston

Research output: Contribution to journalArticle

4 Citations (Scopus)
84 Downloads (Pure)

Abstract

Background: The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods: 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwent whole body angiogram and cardiac MR in a 3 T scanner. The arterial tree was subdivided into 31 segments and each scored according to the degree of stenosis. From this a standardised atheroma score (SAS) was calculated. Cine and late gadolinium enhancement images of the left ventricle were obtained. Results: Asymptomatic atherosclerotic disease with greater than 50 % stenosis in arteries other than that responsible for their presenting complain was detected in 37 % of CAD, 33 % of cerebrovascular and 47 % of PAD patients. Unrecognised myocardial infarcts were observed in 29 % of PAD patients. SAS was significantly higher in PAD patients 24 (17.5-30.5) compared to CAD 4 (2-11.25) or cerebrovascular disease patients 6 (2-10) (ANCOVA p <0.001). Standardised atheroma score positively correlated with age (β 0.36 p = 0.002), smoking status (β 0.34 p = 0.002), and LV mass (β -0.61 p = 0.001) on multiple linear regression. Conclusion: WB CVMR is an effective method for the stratification of cardiovascular disease. The high prevalence of asymptomatic arterial disease, and silent myocardial infarctions, particularly in the peripheral arterial disease group, demonstrates the importance of a systematic approach to the assessment of cardiovascular disease.

Original languageEnglish
Article number18
Number of pages10
JournalBMC Medical Imaging
Volume16
DOIs
Publication statusPublished - 29 Feb 2016

Fingerprint

Peripheral Arterial Disease
Cardiovascular Diseases
Magnetic Resonance Imaging
Atherosclerotic Plaques
Cerebrovascular Disorders
Asymptomatic Diseases
Coronary Artery Disease
Vascular Diseases
Pathologic Constriction
Myocardial Infarction
Image Enhancement
Gadolinium
Heart Ventricles
Linear Models
Atherosclerosis
Angiography
Arteries
Smoking

Keywords

  • Atheroma burden
  • Atherosclerosis
  • Cerebrovascular disease
  • Coronary artery disease
  • Peripheral arterial disease
  • Whole body magnetic resonance angiography

Cite this

@article{849b21322f3348ed9d3ef4ea326139fb,
title = "Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease",
abstract = "Background: The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods: 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwent whole body angiogram and cardiac MR in a 3 T scanner. The arterial tree was subdivided into 31 segments and each scored according to the degree of stenosis. From this a standardised atheroma score (SAS) was calculated. Cine and late gadolinium enhancement images of the left ventricle were obtained. Results: Asymptomatic atherosclerotic disease with greater than 50 {\%} stenosis in arteries other than that responsible for their presenting complain was detected in 37 {\%} of CAD, 33 {\%} of cerebrovascular and 47 {\%} of PAD patients. Unrecognised myocardial infarcts were observed in 29 {\%} of PAD patients. SAS was significantly higher in PAD patients 24 (17.5-30.5) compared to CAD 4 (2-11.25) or cerebrovascular disease patients 6 (2-10) (ANCOVA p <0.001). Standardised atheroma score positively correlated with age (β 0.36 p = 0.002), smoking status (β 0.34 p = 0.002), and LV mass (β -0.61 p = 0.001) on multiple linear regression. Conclusion: WB CVMR is an effective method for the stratification of cardiovascular disease. The high prevalence of asymptomatic arterial disease, and silent myocardial infarctions, particularly in the peripheral arterial disease group, demonstrates the importance of a systematic approach to the assessment of cardiovascular disease.",
keywords = "Atheroma burden, Atherosclerosis, Cerebrovascular disease, Coronary artery disease, Peripheral arterial disease, Whole body magnetic resonance angiography",
author = "Weir-McCall, {Jonathan R.} and Duce, {Suzanne L.} and Gandy, {Stephen J.} and Matthew, {Shona Z.} and Patricia Martin and Cassidy, {Deirdre B.} and Lynne McCormick and Belch, {Jill J F} and Struthers, {Allan D.} and Colhoun, {Helen M.} and Houston, {J. Graeme}",
year = "2016",
month = "2",
day = "29",
doi = "10.1186/s12880-016-0121-4",
language = "English",
volume = "16",
journal = "BMC Medical Imaging",
issn = "1471-2342",
publisher = "Springer Verlag",

}

Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease. / Weir-McCall, Jonathan R. (Lead / Corresponding author); Duce, Suzanne L.; Gandy, Stephen J.; Matthew, Shona Z.; Martin, Patricia; Cassidy, Deirdre B.; McCormick, Lynne; Belch, Jill J F; Struthers, Allan D.; Colhoun, Helen M.; Houston, J. Graeme.

In: BMC Medical Imaging, Vol. 16, 18, 29.02.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Whole body cardiovascular magnetic resonance imaging to stratify symptomatic and asymptomatic atherosclerotic burden in patients with isolated cardiovascular disease

AU - Weir-McCall, Jonathan R.

AU - Duce, Suzanne L.

AU - Gandy, Stephen J.

AU - Matthew, Shona Z.

AU - Martin, Patricia

AU - Cassidy, Deirdre B.

AU - McCormick, Lynne

AU - Belch, Jill J F

AU - Struthers, Allan D.

AU - Colhoun, Helen M.

AU - Houston, J. Graeme

PY - 2016/2/29

Y1 - 2016/2/29

N2 - Background: The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods: 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwent whole body angiogram and cardiac MR in a 3 T scanner. The arterial tree was subdivided into 31 segments and each scored according to the degree of stenosis. From this a standardised atheroma score (SAS) was calculated. Cine and late gadolinium enhancement images of the left ventricle were obtained. Results: Asymptomatic atherosclerotic disease with greater than 50 % stenosis in arteries other than that responsible for their presenting complain was detected in 37 % of CAD, 33 % of cerebrovascular and 47 % of PAD patients. Unrecognised myocardial infarcts were observed in 29 % of PAD patients. SAS was significantly higher in PAD patients 24 (17.5-30.5) compared to CAD 4 (2-11.25) or cerebrovascular disease patients 6 (2-10) (ANCOVA p <0.001). Standardised atheroma score positively correlated with age (β 0.36 p = 0.002), smoking status (β 0.34 p = 0.002), and LV mass (β -0.61 p = 0.001) on multiple linear regression. Conclusion: WB CVMR is an effective method for the stratification of cardiovascular disease. The high prevalence of asymptomatic arterial disease, and silent myocardial infarctions, particularly in the peripheral arterial disease group, demonstrates the importance of a systematic approach to the assessment of cardiovascular disease.

AB - Background: The aim of this study was to use whole body cardiovascular magnetic resonance imaging (WB CVMR) to assess the heart and arterial network in a single examination, so as to describe the burden of atherosclerosis and subclinical disease in participants with symptomatic single site vascular disease. Methods: 64 patients with a history of symptomatic single site vascular disease (38 coronary artery disease (CAD), 9 cerebrovascular disease, 17 peripheral arterial disease (PAD)) underwent whole body angiogram and cardiac MR in a 3 T scanner. The arterial tree was subdivided into 31 segments and each scored according to the degree of stenosis. From this a standardised atheroma score (SAS) was calculated. Cine and late gadolinium enhancement images of the left ventricle were obtained. Results: Asymptomatic atherosclerotic disease with greater than 50 % stenosis in arteries other than that responsible for their presenting complain was detected in 37 % of CAD, 33 % of cerebrovascular and 47 % of PAD patients. Unrecognised myocardial infarcts were observed in 29 % of PAD patients. SAS was significantly higher in PAD patients 24 (17.5-30.5) compared to CAD 4 (2-11.25) or cerebrovascular disease patients 6 (2-10) (ANCOVA p <0.001). Standardised atheroma score positively correlated with age (β 0.36 p = 0.002), smoking status (β 0.34 p = 0.002), and LV mass (β -0.61 p = 0.001) on multiple linear regression. Conclusion: WB CVMR is an effective method for the stratification of cardiovascular disease. The high prevalence of asymptomatic arterial disease, and silent myocardial infarctions, particularly in the peripheral arterial disease group, demonstrates the importance of a systematic approach to the assessment of cardiovascular disease.

KW - Atheroma burden

KW - Atherosclerosis

KW - Cerebrovascular disease

KW - Coronary artery disease

KW - Peripheral arterial disease

KW - Whole body magnetic resonance angiography

UR - http://www.scopus.com/inward/record.url?scp=84959376935&partnerID=8YFLogxK

U2 - 10.1186/s12880-016-0121-4

DO - 10.1186/s12880-016-0121-4

M3 - Article

C2 - 26923316

AN - SCOPUS:84959376935

VL - 16

JO - BMC Medical Imaging

JF - BMC Medical Imaging

SN - 1471-2342

M1 - 18

ER -