Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

Lesley A. McLaughlin, Mark J.I. Paine, Carol A. Kemp, Jean Didier Maréchal, Jack U. Flanagan, Clive J. Ward, Michael J. Sutcliffe, Gordon C.K. Roberts, C. Roland Wolf

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    Biochemistry, Genetics and Molecular Biology

    Chemistry

    Pharmacology, Toxicology and Pharmaceutical Science