Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

Philip Cohen, Marianna Tcherpakov

    Research output: Contribution to journalArticle

    202 Citations (Scopus)

    Abstract

    Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug discovery programs that target components of the ubiquitin system have lagged behind. In this Perspective, we discuss the reasons for the delay in this pipeline, the drugs targeting the ubiquitin system that have been developed, and new approaches that may popularize this area of drug discovery in the future.

    Original languageEnglish
    Pages (from-to)686-693
    Number of pages8
    JournalCell
    Volume143
    Issue number5
    DOIs
    Publication statusPublished - 24 Nov 2010

    Keywords

    • SMALL-MOLECULE INHIBITOR
    • UNANCHORED POLYUBIQUITIN CHAINS
    • KAPPA-B ACTIVATION
    • DEUBIQUITINATING ENZYME
    • DNA-DAMAGE
    • LIGASE
    • PROTEASOME
    • MDM2
    • P53
    • IDENTIFICATION

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