WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi; Jinwei Zhang; Arjun R. Khanna; David H. Ellison; Eric Delpire; Kristopher T. Kahle

doi:10.1016/j.cmet.2017.01.007

WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David H. Ellison, Eric Delpire, Kristopher T. Kahle (Lead / Corresponding author)

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Research output: Contribution to journal › Review article › peer-review

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Abstract

WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl(-) cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Original language	English
Pages (from-to)	285-299
Number of pages	15
Journal	Cell Metabolism
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2017.01.007
Publication status	Published - 7 Feb 2017

Keywords

NKCC1
KCC2
KCC3
NCC
WNKI1
WNK3
WNK4
chloride
GABA
kidney
homeostasis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cmet.2017.01.007

Author Accepted Manuscript
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 830 KBLicence: CC BY-NC-ND

Cite this

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title = "WNK Kinase Signaling in Ion Homeostasis and Human Disease",

abstract = "WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl(-) cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.",

keywords = "NKCC1, KCC2, KCC3, NCC, WNKI1, WNK3, WNK4, chloride, GABA, kidney, homeostasis",

author = "Masoud Shekarabi and Jinwei Zhang and Khanna, {Arjun R.} and Ellison, {David H.} and Eric Delpire and Kahle, {Kristopher T.}",

note = "This work was supported by a NIHNRCDP grant (K.T.K.), Simons Foundation grant #400947 (K.T.K.), March of Dimes Basil O{\textquoteright}Connor Award (K.T.K.), and NIH grant DK93501 to E.D.",

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doi = "10.1016/j.cmet.2017.01.007",

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TY - JOUR

T1 - WNK Kinase Signaling in Ion Homeostasis and Human Disease

AU - Shekarabi, Masoud

AU - Zhang, Jinwei

AU - Khanna, Arjun R.

AU - Ellison, David H.

AU - Delpire, Eric

AU - Kahle, Kristopher T.

N1 - This work was supported by a NIHNRCDP grant (K.T.K.), Simons Foundation grant #400947 (K.T.K.), March of Dimes Basil O’Connor Award (K.T.K.), and NIH grant DK93501 to E.D.

PY - 2017/2/7

Y1 - 2017/2/7

N2 - WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl(-) cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

AB - WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl(-) cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

KW - NKCC1

KW - KCC2

KW - KCC3

KW - NCC

KW - WNKI1

KW - WNK3

KW - WNK4

KW - chloride

KW - GABA

KW - kidney

KW - homeostasis

U2 - 10.1016/j.cmet.2017.01.007

DO - 10.1016/j.cmet.2017.01.007

M3 - Review article

C2 - 28178566

SN - 1550-4131

VL - 25

SP - 285

EP - 299

JO - Cell Metabolism

JF - Cell Metabolism

IS - 2

ER -

WNK Kinase Signaling in Ion Homeostasis and Human Disease

Abstract

Keywords

UN SDGs

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