WNK Kinase Signaling in Ion Homeostasis and Human Disease

Masoud Shekarabi, Jinwei Zhang, Arjun R. Khanna, David H. Ellison, Eric Delpire, Kristopher T. Kahle (Lead / Corresponding author)

Research output: Contribution to journalReview articlepeer-review

151 Citations (Scopus)
254 Downloads (Pure)


WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl(-) cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.

Original languageEnglish
Pages (from-to)285-299
Number of pages15
JournalCell Metabolism
Issue number2
Publication statusPublished - 7 Feb 2017


  • NKCC1
  • KCC2
  • KCC3
  • NCC
  • WNKI1
  • WNK3
  • WNK4
  • chloride
  • GABA
  • kidney
  • homeostasis


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