Abstract
The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
| Original language | English |
|---|---|
| Pages (from-to) | 1760-1767 |
| Number of pages | 8 |
| Journal | Journal of Investigative Dermatology |
| Volume | 136 |
| Issue number | 9 |
| Early online date | 19 Jul 2016 |
| DOIs | |
| Publication status | Published - Sept 2016 |
Access to Document
- Author Accepted Manuscript
© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/