The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
Sherwood, V., & Leigh, I. (2016). WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy? Journal of Investigative Dermatology, 136(9), 1760-1767. https://doi.org/10.1016/j.jid.2016.05.108