WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Victoria Sherwood (Lead / Corresponding author), Irene Leigh

    Research output: Contribution to journalReview article

    5 Citations (Scopus)
    185 Downloads (Pure)

    Abstract

    The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
    Original languageEnglish
    Pages (from-to)1760-1767
    Number of pages8
    JournalJournal of Investigative Dermatology
    Volume136
    Issue number9
    Early online date19 Jul 2016
    DOIs
    Publication statusPublished - Sep 2016

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