WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Victoria Sherwood; Irene Leigh

doi:10.1016/j.jid.2016.05.108

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Victoria Sherwood (Lead / Corresponding author), Irene Leigh

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

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Abstract

The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

Original language	English
Pages (from-to)	1760-1767
Number of pages	8
Journal	Journal of Investigative Dermatology
Volume	136
Issue number	9
Early online date	19 Jul 2016
DOIs	https://doi.org/10.1016/j.jid.2016.05.108
Publication status	Published - Sept 2016

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© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 673 KBLicence: CC BY-NC-ND

Cite this

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title = "WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?",

abstract = "The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.",

author = "Victoria Sherwood and Irene Leigh",

note = "This work was supported by Cancer Research UK and Tenovus Scotland.",

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T1 - WNT Signaling in Cutaneous Squamous Cell Carcinoma

T2 - A Future Treatment Strategy?

AU - Sherwood, Victoria

AU - Leigh, Irene

N1 - This work was supported by Cancer Research UK and Tenovus Scotland.

PY - 2016/9

Y1 - 2016/9

N2 - The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

AB - The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

U2 - 10.1016/j.jid.2016.05.108

DO - 10.1016/j.jid.2016.05.108

M3 - Review article

C2 - 27448706

SN - 0022-202X

VL - 136

SP - 1760

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 9

ER -

WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Abstract

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