WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?

Victoria Sherwood (Lead / Corresponding author), Irene Leigh

    Research output: Contribution to journalReview article

    5 Citations (Scopus)
    127 Downloads (Pure)

    Abstract

    The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.
    Original languageEnglish
    Pages (from-to)1760-1767
    Number of pages8
    JournalJournal of Investigative Dermatology
    Volume136
    Issue number9
    Early online date19 Jul 2016
    DOIs
    Publication statusPublished - Sep 2016

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    Squamous Cell Carcinoma
    Skin
    Oncology
    Skin Neoplasms
    Tumors
    Neoplasms
    Epithelial Cells
    Therapeutics

    Cite this

    @article{c521c1078e0a4c7f87adfe0687c79020,
    title = "WNT Signaling in Cutaneous Squamous Cell Carcinoma: A Future Treatment Strategy?",
    abstract = "The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.",
    author = "Victoria Sherwood and Irene Leigh",
    note = "This work was supported by Cancer Research UK and Tenovus Scotland.",
    year = "2016",
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    doi = "10.1016/j.jid.2016.05.108",
    language = "English",
    volume = "136",
    pages = "1760--1767",
    journal = "Journal of Investigative Dermatology",
    issn = "0022-202X",
    publisher = "Nature Publishing Group",
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    }

    WNT Signaling in Cutaneous Squamous Cell Carcinoma : A Future Treatment Strategy? / Sherwood, Victoria (Lead / Corresponding author); Leigh, Irene.

    In: Journal of Investigative Dermatology, Vol. 136, No. 9, 09.2016, p. 1760-1767.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - WNT Signaling in Cutaneous Squamous Cell Carcinoma

    T2 - A Future Treatment Strategy?

    AU - Sherwood, Victoria

    AU - Leigh, Irene

    N1 - This work was supported by Cancer Research UK and Tenovus Scotland.

    PY - 2016/9

    Y1 - 2016/9

    N2 - The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

    AB - The molecular mechanisms underlying cutaneous squamous cell carcinoma are less well established than other common skin cancers, but recent evidence has highlighted a potentially critical role for WNT signaling in both the development and progression of cSCC. WNT pathways are aberrantly regulated in multiple tumour types (albeit in a context-dependent manner) and this has stimulated the development of WNT inhibitory compounds for cancer treatment. In this review, we examine existing evidence for a role of WNT signaling in cSCC and discuss if WNT inhibition represents a realistic therapeutic strategy for the future.

    U2 - 10.1016/j.jid.2016.05.108

    DO - 10.1016/j.jid.2016.05.108

    M3 - Review article

    C2 - 27448706

    VL - 136

    SP - 1760

    EP - 1767

    JO - Journal of Investigative Dermatology

    JF - Journal of Investigative Dermatology

    SN - 0022-202X

    IS - 9

    ER -