ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

Mahima Swamy (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

Abstract

A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.
Original languageEnglish
Pages (from-to)1293-1294
Number of pages2
JournalNature Immunology
Volume23
Early online date31 Aug 2022
DOIs
Publication statusPublished - Sep 2022

Keywords

  • Lymphocyte activation
  • Signal transduction
  • T cells

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