ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

Mahima Swamy

doi:10.1038/s41590-022-01297-w

ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

Mahima Swamy (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

317 Downloads (Pure)

Abstract

A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.

Original language	English
Pages (from-to)	1293-1294
Number of pages	2
Journal	Nature Immunology
Volume	23
Early online date	31 Aug 2022
DOIs	https://doi.org/10.1038/s41590-022-01297-w
Publication status	Published - Sept 2022

Keywords

Lymphocyte activation
Signal transduction
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/s41590-022-01297-w

Author Accepted ManuscriptAccepted author manuscript, 806 KB

Cite this

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title = "ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination",

abstract = "A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.",

keywords = "Lymphocyte activation, Signal transduction, T cells",

author = "Mahima Swamy",

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doi = "10.1038/s41590-022-01297-w",

language = "English",

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KW - Lymphocyte activation

KW - Signal transduction

KW - T cells

UR - https://www.scopus.com/pages/publications/85137951149

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DO - 10.1038/s41590-022-01297-w

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JO - Nature Immunology

JF - Nature Immunology

ER -

ZAP70 holds the key to kinetic proofreading for TCR ligand discrimination

Abstract

Keywords

ASJC Scopus subject areas

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