Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2

Michael McMahon (Lead / Corresponding author), Samuel R. Swift, John D. Hayes (Lead / Corresponding author)

Centre for Advanced Scientific Technologies

Research output: Contribution to journal › Article › peer-review

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Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)
Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator), Henderson, C. (Investigator), Keyse, S. (Investigator), Lamond, A. (Investigator) & Sutherland, C. (Investigator)
Medical Research Council
1/05/16 → 31/10/19
Project: Research