Development of Next-Generation Protein Degradation Systems
: BromoTag and Other PROTACs

Adam George Bond

Biological Chemistry and Drug Discovery

Student thesis: Doctoral Thesis › Doctor of Philosophy

Date of Award	2022
Original language	English
Awarding Institution	University of Dundee
Supervisor	Alessio Ciulli (Supervisor) & Gopal Sapkota (Supervisor)

Keywords

PROTAC
Targeted Protein Degradation
Organic Chemistry
Medicinal Chemistry

Cite this

Links

10.15132/20000266

Related content

Research Outputs
Mechanistic and Structural Features of PROTAC Ternary Complexes
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Development of BromoTag: A “Bump-&-Hole”-PROTAC system to induce potent, rapid, and selective degradation of tagged target proteins
Research output: Contribution to journal › Article › peer-review
Stereoselective synthesis of allele-specific BET inhibitors
Research output: Contribution to journal › Article › peer-review
Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity
Research output: Contribution to journal › Article › peer-review

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