Function of two closely related fibroblast growth factors in early mesoderm development of Drosophila melanogaster

  • Anna Klingseisen

    Student thesis: Doctoral ThesisDoctor of Philosophy


    Thisbe (Ths) and Pyramus (Pyr) are the ligands for the Fibroblast-Growth-Factor (FGF)receptor Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during organogenesis, loss and gain of function studies were performed. In an approach of functional analysis, a single mutant allele of ths was generated, ths759, for comparison of the single mutant conditions of ths and the null mesodermal cells to migrate and differentiate in a precise pattern.
    Date of Award2009
    Original languageEnglish
    SupervisorHans-Arno Muller (Supervisor)


    • Gastrulation
    • Mesoderm migration
    • Heart development
    • Fibroblast growth factor

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