Investigating the role of the mRNA capping enzymes in mouse embryonic stem cells and differentiation

  • Joana Clara Silva

Student thesis: Doctoral ThesisDoctor of Philosophy

Abstract

The mRNA cap consists of a series of co-transcriptional modifications on nascent transcripts that confer protection from degradation and mediate RNA processing and translation. The addition of an inverted guanosine cap to the 5’-end of the transcript and its subsequent methylation along with the methylation of the first and second transcribed nucleotides are catalysed by several enzymes to form a complete cap structure. Growing evidence suggests that the mRNA cap and the mRNA capping enzymes can be regulated in a context-dependent manner by different molecules and signalling pathways either through co-factors or posttranslational modifications.
Date of Award2020
Original languageEnglish
SponsorsWellcome Trust
SupervisorVictoria Cowling (Supervisor)

Cite this

Investigating the role of the mRNA capping enzymes in mouse embryonic stem cells and differentiation
Clara Silva, J. (Author). 2020

Student thesis: Doctoral ThesisDoctor of Philosophy