Investigating the role of the mRNA capping enzymes in mouse embryonic stem cells and differentiation

  • Joana Clara Silva

    Student thesis: Doctoral ThesisDoctor of Philosophy


    The mRNA cap consists of a series of co-transcriptional modifications on nascent transcripts that confer protection from degradation and mediate RNA processing and translation. The addition of an inverted guanosine cap to the 5’-end of the transcript and its subsequent methylation along with the methylation of the first and second transcribed nucleotides are catalysed by several enzymes to form a complete cap structure. Growing evidence suggests that the mRNA cap and the mRNA capping enzymes can be regulated in a context-dependent manner by different molecules and signalling pathways either through co-factors or posttranslational modifications.
    Date of Award2020
    Original languageEnglish
    SponsorsWellcome Trust
    SupervisorVictoria Cowling (Supervisor)

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