The mRNA cap consists of a series of co-transcriptional modifications on nascent transcripts that confer protection from degradation and mediate RNA processing and translation. The addition of an inverted guanosine cap to the 5’-end of the transcript and its subsequent methylation along with the methylation of the first and second transcribed nucleotides are catalysed by several enzymes to form a complete cap structure. Growing evidence suggests that the mRNA cap and the mRNA capping enzymes can be regulated in a context-dependent manner by different molecules and signalling pathways either through co-factors or posttranslational modifications.
| Date of Award | 2020 |
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| Original language | English |
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| Sponsors | Wellcome Trust |
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| Supervisor | Victoria Cowling (Supervisor) |
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Investigating the role of the mRNA capping enzymes in mouse embryonic stem cells and differentiation
Clara Silva, J. (Author). 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy