Molecular mechanisms of thyroid hormone transport
: the role of amino acid transporters

  • James William Alexander Ritchie

    Student thesis: Doctoral ThesisDoctor of Philosophy


    Thyroid hormones (TH) exert their multitude of effects on body development,
    growth and metabolism largely via transcriptional regulatory pathways. TH-induced transcription is controlled by receptors present in the cell nucleus,
    therefore extracellular TH must first cross the plasma membrane to gain entry
    into the cell. The exact mechanisms of TH transport across the plasma
    membrane are only beginning to be clarified, but it is likely that transport may
    be an important control step for the effects of TH on transcription. Members of
    the recently cloned organic anion transporting polypeptide (OATP) family have
    been shown to transport TH. Inhibitor studies indicate that both the aromatic
    amino acid System T-type transporter, and the broad scope neutral amino acid
    transporter System L are mediators of TH uptake into various cell types.
    However cloned amino acid transporters have not been studied to demonstrate
    directly whether they can accept TH as substrates.

    Date of Award2000
    Original languageEnglish
    SponsorsBiotechnology and Biological Sciences Research Council
    SupervisorPeter Taylor (Supervisor)


    • Thyroid hormones
    • Amino acids
    • membrane transport
    • uptake kinetics

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